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Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans.
TLDR
Three-dimensional reconstructions of islets of Langerhans reveal a marked difference in the number of cells containing glucagon and pancreatic polypeptide depending on the anatomical location of the islet in the pancreas, contradicting the assumption that all islets in the Pancreas are similar in their endocrine cell content. Expand
Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.
TLDR
The activation of glutamate dehydrogenase by BCH may account for the insulin-releasing capacity of the leucine analog and be responsible for the dose-related increase in 14CO2 output from islets prelabeled with L-[U-14C]glutamine. Expand
Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.
TLDR
Both the volume density and number of somatostatin- and glucagon-containing cells were significantly increased in the islets of juvenile-type human diabetics and of streptozotocin diabetic rats. Expand
Quantitation of Endocrine Cell Content in the Pancreas of Nondiabetic and Diabetic Humans
TLDR
Small differences between individual endocrine cell volumes are detectable in both IDDM and NIDDM as compared with nondiabetics, but their significance is at present unclear. Expand
Determinants of the selective toxicity of alloxan to the pancreatic B cell.
TLDR
The findings suggest that the selective cytotoxicity of alloxan to the pancreatic B cell is attributable to the conjunction of two features: a rapid cellular uptake of the drug and an exquisite sensitivity of the B cell to peroxide. Expand
Phosphoglucoisomerase-catalyzed interconversion of hexose phosphates: isotopic discrimination between hydrogen and deuterium
TLDR
The discrimination between the isotopes of hydrogen in the reaction catalyzed by yeast phosphoglucoisomerase is examined by NMR, as well as by spectrofluorometric or radioisotopic methods, with little difference in the affinity of the enzyme for these two substrates. Expand
Presence of fructokinase in pancreatic islets
TLDR
Homogenates of rat pancreatic islets that had been heated for 5 min at 70°C to inactive hexokinases, catalysed the ATP‐dependent phosphorylation of D‐fructose, and it was concluded that fructokinase (ketohexokinase) was responsible for this process. Expand
Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets.
TLDR
It is proposed that the insulinotropic action of some artificial sweeteners and, possibly, that of selected hexose pentaacetate esters may require G-protein-coupled receptors similar to those operative in the recognition of bitter compounds by taste buds. Expand
A possible role for the adenylcyclase system in insulin secretion.
TLDR
It is suggested that the beta-cell contains an adenylcyclase system through which phosphorylase and possibly phosphofructokinase could be activated; and that insulin secretion could depend upon and be regulated by hormones and other substances which influence the rate at which glycolysis proceeds within the Beta-cell. Expand
Stimulation of insulin secretion by noncarbohydrate metabolites.
TLDR
It is suggested that oxidation of substrates through the Krebs cycle could provide both the signal and energy required for the process of insulin secretion and that keto-acids, fatty acids, and amino acids might be involved in a feedback control mechanism of insulin gland secretion in vivo, comparable to that existing for glucose. Expand
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