• Publications
  • Influence
Celecoxib for the prevention of sporadic colorectal adenomas.
BACKGROUND Studies showing that drugs that inhibit cyclooxygenase-2 (COX-2) reduce the number of colorectal adenomas in animals and patients with familial adenomatous polyposis suggest that COX-2Expand
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Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
Summary Background Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employedExpand
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Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1.
BACKGROUND & AIMS Germline mutations in mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer. A significant proportion of mutations are nontruncating and associatedExpand
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Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH.
BACKGROUND & AIMS Hyperplastic polyposis syndrome (HPS) is defined phenotypically with multiple, large and/or proximal hyperplastic polyps. There is no known germ-line predisposition. We aimed toExpand
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Five-Year Efficacy and Safety Analysis of the Adenoma Prevention with Celecoxib Trial
The Adenoma Prevention with Celecoxib Trial examined the efficacy and safety of the cyclooxygenase (Cox)-2 inhibitor, celecoxib, for sporadic colorectal adenoma prevention in patients at high riskExpand
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Risks of Lynch syndrome cancers for MSH6 mutation carriers.
BACKGROUND Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies ofExpand
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Histopathology and prognosis of malignant colorectal polyps treated by endoscopic polypectomy.
The histopathological features and results of treatment of malignant polyps removed by endoscopic polypectomy from 60 patients are presented. The patients were followed for a minimum of five years.Expand
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A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer.
A new human colon cancer cell line (LIM1215) has been derived from a tumor arising in a member of a family known to have a high incidence of colorectal cancer. The tumor cell line is comprised ofExpand
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A review of Juvenile Polyposis Syndrome
  • E. Chow, F. Macrae
  • Medicine
  • Journal of gastroenterology and hepatology
  • 1 November 2005
Abstract  Juvenile Polyposis Syndrome is an uncommon hamartomatous disorder with significant gastrointestinal malignant potential. Mutations in SMAD4 and BMPR1A, implicated in the Transforming GrowthExpand
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Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study.
PURPOSE To determine whether cancer risks for carriers and noncarriers from families with a mismatch repair (MMR) gene mutation are increased above the risks of the general population. PATIENTS ANDExpand
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