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Characterization of two oxidatively modified phospholipids in mixed monolayers with DPPC.
TLDR
The data support the view that lipid oxidation modifies both the small-scale structural dynamics of biological membranes as well as their more macroscopic lateral organization. Expand
Biophysics of lipid bilayers containing oxidatively modified phospholipids: insights from fluorescence and EPR experiments and from MD simulations.
TLDR
It was shown that the presence of the investigated oxPCs in phospholipid model membranes may have the following consequences: decrease of the lipid order, lowering of phase transition temperatures, lateral expansion and thinning of the bilayer, alterations of bilayer hydration profiles, increased lipid mobility, and augmented flip-flop. Expand
Oxidized phospholipids induce phase separation in lipid vesicles
TLDR
It is concluded that oxidized lipid induces phase separation in more rigid DPPC‐ rich membranes, while leaving fluidity unaffected in more fluid LPPC‐rich membranes, and at higher temperature. Expand
Different oxidized phospholipid molecules unequally affect bilayer packing.
TLDR
It is concluded that the effects of different oxidized phospholipid bilayer structure cannot be generalized, as happens with batch-oxidizedospholipids, and that the use of defined oxidizer molecular species for membrane oxidative stress guarantees a more reliable and detailed response. Expand
Phospholipidomics of human blood microparticles.
TLDR
The phospholipidome composition of MPs and platelets, collected from the same donors, was found to be qualitatively the same, but quantitative differences were evidenced for lyso-PCs, which appear to be significantly more abundant in MPs. Expand
Improved specificity of cardiolipin peroxidation by soybean lipoxygenase: a liquid chromatography - electrospray ionization mass spectrometry investigation.
TLDR
The enzymatic approach, integrated with a preparative separation step, which could be developed by adapting the chromatographic conditions adopted in the present work for analytical purposes, represents a promising strategy for the synthesis of highly specific mono- or multi-peroxidated derivatives of cardiolipins. Expand
Nonspecific lipid transfer protein (sterol carrier protein 2) is bound to rat liver mitochondria: its role in spontaneous intermembrane phospholipid transfer.
TLDR
Up to 85% of the spontaneous phospholipid transfer between vesicles and rat liver mitochondria was mediated by this transfer protein, and it was demonstrated that the activity in the wash was due to the nonspecific lipid transfer protein (sterol carrier protein 2). Expand
An in vitro ESR study of uncatalyzed rat liver protein-catalyzed spin-labeled phosphatidylcholine exchange.
TLDR
ESR spectrometry is used to study fatty acid spin-labeled phosphatidylcholine exchange from single bilayer donor vesicles to various acceptor systems, and it is made that the spontaneous mechanism is active among intact natural membranes and could be of some importance in vivo. Expand
Spin labeling EPR studies of the properties of oxidized phospholipid-containing lipid vesicles.
TLDR
It is concluded that carboxyacyl lecithins in MLVs tend to disrupt vesicle structure, while conjugated dienes leCithins are more able to affect some physical properties of the bilayer, and that DPPC inMLVs enhances these effects while PLPC shows a better compatibility with the lipoperoxides. Expand
EPR studies of phospholipid bilayers after lipoperoxidation. 1. Inner molecular order and fluidity gradient.
TLDR
It is concluded that the early stages of lipoperoxidation bring about disordering of the phospholipid bilayer interior rather than fluidity alterations, and that prolonged oxidation may result in loss of structural and chemical properties of the bilayer until the structure no longer holds. Expand
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