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Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients.
- M. Chan, L. Chan, +8 authors K. To
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 February 2002
PURPOSE We aimed to investigate the methylation pattern in bladder cancer and assess the diagnostic potential of such epigenetic changes in urine. EXPERIMENTAL DESIGN The methylation status of 7… Expand
Acute renal impairment in coronavirus-associated severe acute respiratory syndrome
Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Background … Expand
The Oxford IgA nephropathy clinicopathological classification is valid for children as well as adults.
To study the predictive value of biopsy lesions in IgA nephropathy in a range of patient ages we retrospectively analyzed the cohort that was used to derive a new classification system for IgA… Expand
Frequent hypermethylation of promoter region of RASSF1A in tumor tissues and voided urine of urinary bladder cancer patients
High frequency loss of 3p21.3 region where RASSF1A located was demonstrated in several tumors. We aimed to investigate the methylation status of RASSF1A and the frequency of LOH in 3p21.3 region in… Expand
Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy.
- K. Lai, J. Leung, +6 authors S. Tang
- Nephrology, dialysis, transplantation : official…
- 20 July 2008
BACKGROUND We have previously documented that human mesangial cell (HMC)-derived tumour necrosis factor-alpha (TNF-alpha) is an important mediator involved in the glomerulo-tubular communication in… Expand
Gene expression of the renin‐angiotensin system in human kidney
- K. Lai, J. Leung, K. B. Lai, W. To, V. T. Yeung, F. M. Lai
- Biology, Medicine
- Journal of hypertension
- 1 January 1998
Background Immunocytochemical studies have revealed that all components of the renin-angiotensin system are widely distributed in human tissues yet the information on the gene expression of the… Expand
Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy.
- K. Lai, J. Leung, +4 authors S. Tang
- American journal of physiology. Renal physiology
- 1 April 2008
We have previously documented that human mesangial cell (HMC)-derived TNF-alpha is an important mediator involved in the glomerulo-tubular communication in the development of interstitial damage in… Expand
Birth prevalence of Down syndrome in Singapore from 1993 to 1998.
OBJECTIVE To examine the livebirth prevalence rate of Down Syndrome in Singapore from 1993 to 1998. DESIGN Index cases for the National Birth Defects Register were obtained from all neonatal… Expand
Up-Regulated Pancreatic Tissue MicroRNA-375 Associates With Human Type 2 Diabetes Through &bgr;-Cell Deficit and Islet Amyloid Deposition
Objectives: The aim of this study was to examine correlations of the islet-specific microRNA-375 expression to islet amyloid formation and pancreatic islet damage in human type 2 diabetes. Methods:… Expand
Amyloid oligomers in diabetic and nondiabetic human pancreas.
The amyloid hypothesis of type 2 diabetes mellitus postulates that elevated levels of normally expressed monomeric proteins of human islet amyloid polypeptide (hIAPP) trigger oligomerization that… Expand