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Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.
- H. Urata, A. Kinoshita, K. Misono, F. M. Bumpus, A. Husain
- Medicine, Chemistry
- The Journal of biological chemistry
- 25 December 1990
Although angiotensin II (Ang II)-forming enzymatic activity in the human left cardiac ventricle is minimally inhibited by angiotensin I (Ang I) converting enzyme inhibitors, over 75% of this activity… Expand
Angiotensin II-forming pathways in normal and failing human hearts.
- H. Urata, B. Healy, R. Stewart, F. M. Bumpus, A. Husain
- Chemistry, Medicine
- Circulation research
- 1 April 1990
Reduced preload and afterload to the heart are important effects of angiotensin converting enzyme (ACE) inhibitors in the treatment of congestive heart failure. However, since angiotensin II (Ang II)… Expand
Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.
- H. Urata, K. D. Boehm, +4 authors A. Husain
- Biology, Medicine
- The Journal of clinical investigation
- 1 April 1993
The human heart is a target organ for the octapeptide hormone, angiotensin II (Ang II). Recent studies suggest that the human heart contains a dual pathway of Ang II formation in which the major Ang… Expand
Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor.
- A. G. Pucell, J. C. Hodges, I Sen, F. M. Bumpus, A. Husain
- Biology, Medicine
- Endocrinology
- 1 April 1991
Angiotensin II (Ang II) receptors, estimated by the specific binding of the peptide Ang II receptor antagonist [125I] [Sar1,Ile8]Ang II, are localized on multiple ovarian structures, including… Expand
Measurement of Renin Activity in Human Plasma
- P. Pickens, F. M. Bumpus, A. Lloyd, R. Smeby, Lrvine H. Page
- Chemistry, Medicine
- Circulation research
- 1 November 1965
A method is described for estimating plasma renin activity by using renin substrate present in plasma. This method differs from other indirect renin assay methods by (1) incubation in the absence of… Expand
Biochemical changes associated with development and reversal of cardiac hypertrophy in spontaneously hypertensive rats.
- S. Sen, R. Tarazi, F. M. Bumpus
- Chemistry, Medicine
- Cardiovascular research
- 1 March 1976
This study is the first report describing the sequence of biochemical alterations of myocardium during the progression of naturally occurring hypertrophy in spontaneously hypertensive rats (SHRs) and… Expand
Synthesis and pharmacology of the octapeptide angiotonin.
- F. M. Bumpus, H. Schwarz, I. Page
- Chemistry, Medicine
- Science
- 3 May 1957
Renin in Rats with Spontaneous Hypertension
- S. Sen, R. Smeby, F. M. Bumpus
- Medicine
- Circulation research
- 1 December 1972
An age-dependent study of plasma renin activity (PRA), kidney renin activity (KRA), and plasma renin substrate was carried out in rats with spontaneous hypertension during the prehypertensive, the… Expand
Angiotensin II receptors in normal and failing human hearts.
- H. Urata, B. Healy, R. Stewart, F. M. Bumpus, A. Husain
- Medicine
- The Journal of clinical endocrinology and…
- 1 July 1989
To demonstrate the existence and help clarify the function of angiotensin II (Ang II) receptors in the human heart, we characterized the cardiac Ang II receptor and examined the levels and… Expand
Cloning of the gene and cDNA for human heart chymase.
- H. Urata, A. Kinoshita, +4 authors A. Husain
- Biology, Medicine
- The Journal of biological chemistry
- 15 September 1991
We have recently identified and characterized a chymotrypsin-like serine proteinase in human heart (human heart chymase) that is the most catalytically efficient enzyme described, thus far, for the… Expand