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Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.
Although angiotensin II (Ang II)-forming enzymatic activity in the human left cardiac ventricle is minimally inhibited by angiotensin I (Ang I) converting enzyme inhibitors, over 75% of this activityExpand
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Angiotensin II-forming pathways in normal and failing human hearts.
Reduced preload and afterload to the heart are important effects of angiotensin converting enzyme (ACE) inhibitors in the treatment of congestive heart failure. However, since angiotensin II (Ang II)Expand
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Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.
The human heart is a target organ for the octapeptide hormone, angiotensin II (Ang II). Recent studies suggest that the human heart contains a dual pathway of Ang II formation in which the major AngExpand
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Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor.
Angiotensin II (Ang II) receptors, estimated by the specific binding of the peptide Ang II receptor antagonist [125I] [Sar1,Ile8]Ang II, are localized on multiple ovarian structures, includingExpand
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Measurement of Renin Activity in Human Plasma
A method is described for estimating plasma renin activity by using renin substrate present in plasma. This method differs from other indirect renin assay methods by (1) incubation in the absence ofExpand
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Biochemical changes associated with development and reversal of cardiac hypertrophy in spontaneously hypertensive rats.
This study is the first report describing the sequence of biochemical alterations of myocardium during the progression of naturally occurring hypertrophy in spontaneously hypertensive rats (SHRs) andExpand
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Synthesis and pharmacology of the octapeptide angiotonin.
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Renin in Rats with Spontaneous Hypertension
An age-dependent study of plasma renin activity (PRA), kidney renin activity (KRA), and plasma renin substrate was carried out in rats with spontaneous hypertension during the prehypertensive, theExpand
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Angiotensin II receptors in normal and failing human hearts.
To demonstrate the existence and help clarify the function of angiotensin II (Ang II) receptors in the human heart, we characterized the cardiac Ang II receptor and examined the levels andExpand
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Cloning of the gene and cDNA for human heart chymase.
We have recently identified and characterized a chymotrypsin-like serine proteinase in human heart (human heart chymase) that is the most catalytically efficient enzyme described, thus far, for theExpand
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