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Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens
Individuals from different populations vary considerably in their susceptibility to immune-related diseases. To understand how genetic variation and natural selection contribute to these differences,Expand
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Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter–gatherers and Bantu-speaking farmers
Two groups of populations with completely different lifestyles—the Pygmy hunter–gatherers and the Bantu-speaking farmers—coexist in Central Africa. We investigated the origins of these two groups andExpand
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A reduced representation approach to population genetic analyses and applications to human evolution.
Second-generation sequencing technologies allow surveys of sequence variation on an unprecedented scale. However, despite the rapid decrease in sequencing costs, collecting whole-genome sequence dataExpand
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Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize various drugs and carcinogens. Functional variability at these genes has been associated with adverseExpand
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Clinal patterns of human Y chromosomal diversity in continental Italy and Greece are dominated by drift and founder effects.
We explored the spatial distribution of human Y chromosomal diversity on a microgeographic scale, by typing 30 population samples from closely spaced locations in Italy and Greece for 9 haplogroupsExpand
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Cross-Population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation
Mapping expression quantitative trait loci (eQTLs) has been shown as a powerful tool to uncover the genetic underpinnings of many complex traits at molecular level. In this paper, we present anExpand
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Multiple Advantageous Amino Acid Variants in the NAT2 Gene in Human Populations
Background Genetic variation at NAT2 has been long recognized as the cause of differential ability to metabolize a wide variety of drugs of therapeutic use. Here, we explore the pattern of geneticExpand
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Efficient Integrative Multi-SNP Association Analysis via Deterministic Approximation of Posteriors.
TLDR
We propose a rigorous inference procedure to perform integrative association analysis incorporating genomic annotations for both traditional GWASs and emerging molecular QTL mapping studies. Expand
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Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
DNA methylation is an epigenetic mark thought to be robust to environmental perturbations on a short time scale. Here, we challenge that view by demonstrating that the infection of human dendriticExpand
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Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe
In order to attain a finer reconstruction of the peopling of southern and central-eastern Europe from the Levant, we determined the frequencies of eight lineages internal to the Y chromosomalExpand
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