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Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection.
Prenatal cytogenetic analysis of 71 fetuses conceived by intracytoplasmic sperm injection (ICSI) resulted in the detection of nine (12.7%) chromosome aberrations including two cases of 47,XXY, fourExpand
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Fluorescence in situ hybridization analysis of two blastomeres from day 3 frozen-thawed embryos followed by analysis of the remaining embryo on day 5.
BACKGROUND Chromosomal mosaicism in human embryos may give rise to false positive or false negative results in preimplantation genetic diagnosis for aneuploidy screening (PGD-AS). Therefore, we haveExpand
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Nuisance foam events and Phaeocystis globosa blooms in Dutch coastal waters analyzed with fuzzy logic
Abstract Phaeocystis globosa is a nuisance algal species because it can cause foam on beaches which are associated with coastal blooms. Models of Phaeocystis have considered its bloom dynamics, butExpand
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The development of cytogenetically normal, abnormal and mosaic embryos: a theoretical model.
Assisted reproduction and preimplantation genetic diagnosis (PGD) involve various complicated techniques, each of them with its own problems. However, the greatest problem with PGD for chromosomeExpand
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The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort.
Use of antiepileptic drugs (AEDs) during pregnancy is associated with an increased risk of congenital malformations. Spina bifida aperta has been linked specifically to valproic acid (VPA) (estimatedExpand
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The role of atmospheric deposition in the eutrophication of the North Sea: A model analysis
This study quantifies the relative contribution of atmospheric deposition to total nitrogen in the southern North Sea in a spatial and temporal context. This is done by means of a biogeochemicalExpand
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Patterns and trends in nutrients and phytoplankton in Dutch coastal waters: comparison of time-series analysis, ecological model simulation, and mesocosm experiments
In the Dutch coastal zone, nutrient and chlorophyll concentrations show gradients of up to one order of magnitude perpendicular to the coast within the first 30‐50 km oVshore. Time-series analysisExpand
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Mathematical modelling as a tool for management in eutrophication control of shallow lakes
The eutrophication model Delwaq-Bloom-Switch is developed to be a functional tool for water management. Therefore it includes nutrients, algal biomass and composition as well as water transparency. AExpand
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Complexity, accuracy and practical applicability of different biogeochemical model versions
Abstract The construction of validated biogeochemical model applications as prognostic tools for the marine environment involves a large number of choices particularly with respect to the level ofExpand
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