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Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.
Platelet-released sphingosine 1-phosphate, linked to Rac- and Rho-dependent cytoskeletal rearrangement, may act late in angiogenesis to stabilize newly formed vessels, which often display abnormally increased vascular permeability. Expand
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.
DNA binding studies reveal two mechanisms for generating further diversity from the ATF proteins, and results help to explain how a single promoter element, an ATF site, can be present in a wide variety of promoters. Expand
Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.
Pitx1 gene-deleted mice exhibit striking abnormalities in morphogenesis and growth of the hindlimb, resulting in a limb that exhibits structural changes in tibia and fibula as well as patterning alterations in patella and proximal tarsus, to more closely resemble the corresponding forelimb structures. Expand
The TRAPP complex is a nucleotide exchanger for Ypt1 and Ypt31/32.
TRAPP is a large protein complex that is required for ER-to-Golgi transport and that has properties similar to those of Ypt1 GEF, andCoprecipitation and overexpression studies suggest that TRAPP can act as a GEF for Ypt 1 and Ypt31/32 in vivo. Expand
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
BMP receptors phosphorylate and activate Smad1 directly, providing a link between receptor serine/threonine kinases and the nucleus, and indicating the generality of this process of Smad activation. Expand
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
The isolation of a novel human cDNA encoding a dual-specificity protein kinase (designated Myt1Hu) that preferentially phosphorylates Cdc2 on threonine 14 in a cyclin-dependent manner is reported. Expand
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
The dual function of Smad4 in transcriptional activation underscores its central role in TGFbeta signaling. Expand
Regulation of somatic growth by the p160 coactivator p/CIP.
It is reported that p/CIP, which exhibits regulated transfer from cytoplasm to nucleus, is required for normal somatic growth from embryonic day 13.5 through maturity and both altered regulation of insulin-like growth factor-1 gene expression in specific tissues and a cell-autonomous defect of response to IGF-1 are suggested. Expand
Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas*
It is suggested that the proline-rich domain between amino acids 301 and 315 in PTP1B binds Src homology 3-containing proteins and that p130Cas may be a physiological target of this phosphatase in cells. Expand
Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
  • F. Liu, X. Ma, +6 authors P. Greengard
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 25 September 2001
It is reported that both Cdk5 and CK1 are regulated by metabotropic glutamate receptors (mGluRs) in neostriatal neurons and a CK1-Cdk5-DARPP-32 cascade may be involved in the regulation by mGluR agonists of Ca2+ channels. Expand