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Tau pathology in Alzheimer disease and other tauopathies.
Just as neuronal activity is essential to normal brain function, microtubule-associated protein tau appears to be critical to normal neuronal activity in the mammalian brain, especially in theExpand
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Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
In response to tissue stiffening, fibroblasts increase production of extracellular matrix while decreasing production of matrix-degrading enzymes and the fibrosis inhibitor prostaglandin E2.
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Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
Abnormal hyperphosphorylation of tau is believed to lead to neurofibrillary degeneration in Alzheimer's disease (AD) and other tauopathies. Recent studies have shown that protein phosphatases (PPs)Expand
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Mechanisms of tau-induced neurodegeneration
Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a specific type of slow and progressive neurodegeneration, which involves the abnormal hyperphosphorylation ofExpand
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Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
Brain glucose metabolism is impaired in Alzheimer's disease (AD), the most common form of dementia. Type 2 diabetes mellitus (T2DM) is reported to increase the risk for dementia, including AD, butExpand
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Tau and neurodegenerative disease: the story so far
In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain. In the previous year, a paired helical filament (PHF) protein had been identified in neurofibrillaryExpand
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The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles
The discovery that microRNAs (miRNAs) play important roles in regulating gene expression via posttranscriptional repression has revealed a previously unsuspected mechanism controlling development andExpand
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HOTAIR forms an intricate and modular secondary structure.
Long noncoding RNAs (lncRNAs) have recently emerged as key players in fundamental cellular processes and diseases, but their functions are poorly understood. HOTAIR is a 2,148-nt-long lncRNA moleculeExpand
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ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding
DEAD-box proteins, the largest helicase family, catalyze ATP-dependent remodeling of RNA–protein complexes and the unwinding of RNA duplexes. Because DEAD-box proteins hydrolyze ATP in anExpand
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Tau exon 10 alternative splicing and tauopathies
  • F. Liu, C. Gong
  • Biology, Medicine
  • Molecular Neurodegeneration
  • 10 July 2008
Abnormalities of microtubule-associated protein tau play a central role in neurofibrillary degeneration in several neurodegenerative disorders that collectively called tauopathies. Six isoforms ofExpand
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