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- Publications
- Influence
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
- J. Lambert, S. Heath, +47 authors P. Amouyel
- Biology, Medicine
- Nature Genetics
- 1 September 2009
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide… Expand
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
- P. Hollingworth, D. Harold, +169 authors J. Williams
- Biology, Medicine
- Nature Genetics
- 3 April 2011
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium… Expand
Homocysteine and folate as risk factors for dementia and Alzheimer disease.
- G. Ravaglia, P. Forti, +5 authors F. Licastro
- Medicine
- The American journal of clinical nutrition
- 2005
BACKGROUND
In cross-sectional studies, elevated plasma total homocysteine (tHcy) concentrations have been associated with cognitive impairment and dementia. Incidence studies of this issue are few… Expand
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
- E. Génin, D. Hannequin, +50 authors D. Campion
- Biology, Medicine
- Molecular Psychiatry
- 10 May 2011
Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated AD… Expand
Association of early‐onset Alzheimer's disease with an interleukin‐1α gene polymorphism
- L. Grimaldi, V. M. Casadei, +10 authors M. Franceschi
- Biology, Medicine
- Annals of neurology
- 1 March 2000
Overexpression of the pluripotent cytokine interleukin‐1 (IL‐1) by microglial cells correlates with formation of neuritic β‐amyloid plaques in Alzheimer's disease (AD). We evaluated polymorphisms in… Expand
Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?
- F. Licastro, S. Pedrini, L. Caputo, G. Annoni, L. Grimaldi
- Medicine
- Journal of Neuroimmunology
- 1 February 2000
Plasma concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), C reactive protein (CRP) and alpha-1-antichymotrypsin (ACT) in 145 patients with probable Alzheimer's disease (AD) and 51… Expand
Herpes virus in Alzheimer's disease: relation to progression of the disease
- Ilaria Carbone, T. Lazzarotto, M. Ianni, E. Porcellini, F. Licastro
- Biology, Medicine
- Neurobiology of Aging
- 31 January 2014
Studies regarding different viruses of the herpes family, such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), or human herpes virus 6 (HHV-6) in Alzheimer's disease (AD) are scarce. DNA from… Expand
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
- F. Licastro, G. Candore, +4 authors C. Caruso
- Medicine
- Immunity & Ageing
- 18 May 2005
The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at a price when immunity is involved, namely systemic inflammation. Inflammation… Expand
Interleukin-6 gene alleles affect the risk of Alzheimer’s disease and levels of the cytokine in blood and brain
- F. Licastro, L. Grimaldi, M. Bonafè, Chiappelli Martina, C. Franceschi
- Biology, Medicine
- Neurobiology of Aging
- 1 November 2003
Two different polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease (AD) and non-demented controls. The -174 C allele in the promoter region of… Expand
Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease
- D. Lio, F. Licastro, +7 authors C. Caruso
- Biology, Medicine
- Genes and Immunity
- 1 April 2003
Proinflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their high production have been… Expand