• Publications
  • Influence
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wideExpand
  • 1,260
  • 122
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic ConsortiumExpand
  • 1,454
  • 85
  • PDF
Homocysteine and folate as risk factors for dementia and Alzheimer disease.
BACKGROUND In cross-sectional studies, elevated plasma total homocysteine (tHcy) concentrations have been associated with cognitive impairment and dementia. Incidence studies of this issue are fewExpand
  • 342
  • 17
  • PDF
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated ADExpand
  • 401
  • 16
Association of early‐onset Alzheimer's disease with an interleukin‐1α gene polymorphism
Overexpression of the pluripotent cytokine interleukin‐1 (IL‐1) by microglial cells correlates with formation of neuritic β‐amyloid plaques in Alzheimer's disease (AD). We evaluated polymorphisms inExpand
  • 341
  • 13
Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?
Plasma concentrations of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), C reactive protein (CRP) and alpha-1-antichymotrypsin (ACT) in 145 patients with probable Alzheimer's disease (AD) and 51Expand
  • 347
  • 8
  • PDF
Herpes virus in Alzheimer's disease: relation to progression of the disease
Studies regarding different viruses of the herpes family, such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), or human herpes virus 6 (HHV-6) in Alzheimer's disease (AD) are scarce. DNA fromExpand
  • 84
  • 7
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at a price when immunity is involved, namely systemic inflammation. InflammationExpand
  • 409
  • 6
  • PDF
Interleukin-6 gene alleles affect the risk of Alzheimer’s disease and levels of the cytokine in blood and brain
Two different polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease (AD) and non-demented controls. The -174 C allele in the promoter region ofExpand
  • 167
  • 5
Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease
Proinflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their high production have beenExpand
  • 116
  • 4