• Publications
  • Influence
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
In cancer treatment, apoptosis is a well-recognized cell death mechanism through which cytotoxic agents kill tumor cells. Here we report that dying tumor cells use the apoptotic process to generateExpand
  • 508
  • 25
Apoptotic Cells Activate the “Phoenix Rising” Pathway to Promote Wound Healing and Tissue Regeneration
Caspases in dying cells trigger the release of growth signals that promote tissue repair. Rising from the Dead Tissue injury causes cell death. Apoptotic cell death enables the elimination of damagedExpand
  • 341
  • 18
The C5a Receptor Impairs IL-12–Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss
The C5a anaphylatoxin receptor (C5aR; CD88) is activated as part of the complement cascade and exerts important inflammatory, antimicrobial, and regulatory functions, at least in part, via crosstalkExpand
  • 141
  • 18
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Significance For more than three decades since the discovery of HIV-1, AIDS remains a major public health problem affecting greater than 35.3 million people worldwide. Current antiretroviral therapyExpand
  • 359
  • 17
Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans
DNA double-strand break repair has a central role in oocyte aging. Preserving Fertility Breeds Flexibility Last month, the U.K. Office for National Statistics reported that, in 2010, ~48% of infantsExpand
  • 254
  • 15
Regulation of HIF-1alpha stability through S-nitrosylation.
Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional factor. Under normal oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent degradation of one of itsExpand
  • 199
  • 13
A process-based fire parameterization of intermediate complexity in a Dynamic Global Vegetation Model
Abstract. A process-based fire parameterization of intermediate complexity has been developed for global simulations in the framework of a Dynamic Global Vegetation Model (DGVM) in an Earth SystemExpand
  • 106
  • 13
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells
Transplantation of exogenous dopaminergic neuron (DA neurons) is a promising approach for treating Parkinson's disease (PD). However, a major stumbling block has been the lack of a reliable source ofExpand
  • 148
  • 12
Effects of Temperature and Carbon-Nitrogen (C/N) Ratio on the Performance of Anaerobic Co-Digestion of Dairy Manure, Chicken Manure and Rice Straw: Focusing on Ammonia Inhibition
Anaerobic digestion is a promising alternative to disposal organic waste and co-digestion of mixed organic wastes has recently attracted more interest. This study investigated the effects ofExpand
  • 155
  • 12
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
Neurovascular dysfunction substantially contributes to Alzheimer disease. Here, we show that transcriptional profiling of human brain endothelial cells (BECs) defines a subset of genes whoseExpand
  • 229
  • 11