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The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
TLDR
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetoimmunopharmacology.org) is an expert-curated resource of ligand–activity–target relationships, selected from high-quality pharmacological and medicinal chemistry literature. Expand
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Role of reactive oxygen species (ROS) in apoptosis induction
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and targetExpand
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Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair
Nerve growth factor (NGF) is a polypeptide which, in addition to its effect on nerve cells, is believed to play a role in inflammatory responses and in tissue repair. Because fibroblasts representExpand
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Intracellular delivery mediated by an ethosomal carrier.
The goal of this work was to investigate the efficiency of transcellular delivery into Swiss albino mice 3T3 fibroblasts of molecules with various physico-chemical characteristics from ethosomes,Expand
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The human mast cell.
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What is the physiological function of mast cells?
Abstract:  Under physiological conditions, skin mast cells preferentially localize around nerves, blood vessels and hair follicles. This observation, which dates back to Paul Ehrlich, intuitivelyExpand
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The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
Allergic, inflammatory, and immune responses carried out by eosinophils are regulated by the cross talk between activatory and inhibitory signals. While much data has been obtained on activatoryExpand
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Intracellular localization of interleukin-6 in eosinophils from atopic asthmatics and effects of interferon gamma.
Eosinophils, prominent cells in asthmatic inflammation, have been shown to synthesize, store, and release an array of up to 18 cytokines and growth factors, including interleukin-6 (IL-6). In thisExpand
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Food allergy as a risk factor for life-threatening asthma in childhood: a case-controlled study.
BACKGROUND No objective clinical risk factors exist for pediatric life-threatening asthma. OBJECTIVES In this study, we address whether persistent food allergy and degree of atopy are risk factorsExpand
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Anti‐apoptotic signals of granulocyte‐macrophage colony‐stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils
Cytokine‐mediated inhibition of eosinophil apoptosis is a mechanism causing tissue eosinophilia. Previously published work suggested that activation of the Lyn‐Ras‐Raf‐1‐MAP kinase pathway isExpand
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