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KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current
It is shown that KVLQT1 associates with IsK to form the channel underlying the IKS cardiac current, which is a target of class-Ill anti-arrhythmic drugs and is involved in the L QT1 syndrome. Expand
TASK, a human background K+ channel to sense external pH variations near physiological pH
TASK is a new member of the recently recognized TWIK K+ channel family that has four transmembrane segments and two P domains and in adult human, TASK transcripts are found in pancreas. Expand
Inhalational anesthetics activate two-pore-domain background K+ channels
It is shown that TASK and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics. Expand
A mammalian two pore domain mechano‐gated S‐like K+ channel
A cloned mammalian two P domain K+ channel sharing the properties of the S channel is identified and it is found that the cytoplasmic C‐terminus contains a charged region critical for chemical and mechanical activation, as well as a phosphorylation site required for cAMP inhibition. Expand
Molecular and functional properties of two-pore-domain potassium channels.
  • F. Lesage, M. Lazdunski
  • Chemistry, Medicine
  • American journal of physiology. Renal physiology
  • 1 November 2000
The recent demonstration that TASK-1 and TREk-1 channels are activated by inhalational general anesthetics, and that TRAAK is activated by the neuroprotective agent riluzole, indicates that this novel class of K(+) channels is an interesting target for new therapeutic developments. Expand
Cloning and Expression of a Novel pH-sensitive Two Pore Domain K+ Channel from Human Kidney*
In human and mouse, TASK-2 is mainly expressed in the kidney, where in situ hybridization shows that it is localized in cortical distal tubules and collecting ducts, suggesting that TASk-2 could play an important role in renal K+ transport. Expand
TWIK‐1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
A new human weakly inward rectifying K+ channel, TWIK‐1, has been isolated and is of particular interest because its mRNA is widely distributed in human tissues, and is particularly abundant in brain and heart. Expand
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.
The results provide the first evidence for the existence of a K+ channel family with four TMS and two pore domains in the nervous system of mammals and show that different members in this structural family can have totally different functional properties. Expand
RIM Binding Proteins (RBPs) Couple Rab3-Interacting Molecules (RIMs) to Voltage-Gated Ca2+ Channels
It is shown that RIM binding proteins (RBPs), which associate with Ca(2+) channels in hair cells, photoreceptors, and neurons, interact with alpha(1D) (L type) andalpha(1B) (N type) Ca( 2+) channel subunits. Expand
TREK‐1 is a heat‐activated background K+ channel
Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres asExpand