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A refined molecular taxonomy of breast cancer
TLDR
The data indicate that these six molecular subgroups represent well-defined clinico-biological entities of breast cancer and their identification should facilitate the detection of novel prognostic factors or therapeutical targets in breast cancer.
Molecular Profiling of Inflammatory Breast Cancer
TLDR
This study has identified a limited number of signaling pathways that require inappropriate activation for IBC development and identified a gene expression profile, based on MYCN, EREG, and SHH, which discriminated subgroups of IBC patients with good, intermediate, and poor outcome.
Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen.
TLDR
Findings point to NCOR1 as a promising independent predictor of tamoxifen resistance in patients with ERalpha-positive breast tumors, including ERalpha, ERbeta, CCND1, and ERBB2.
Breast cancer with synchronous metastases: survival impact of exclusive locoregional radiotherapy.
TLDR
In the experience, LRT, consisting mainly of exclusive LRR, was associated with improved survival in breast cancer patients with synchronous metastases and may represent an active alternative to surgery.
Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study
TLDR
It is confirmed that the detection of CTC is independently associated with a significantly worse outcome, but mainly during the first 3-4 years of follow-up, while prechemotherapy CTC and triple negative phenotype were the two independent prognostic factors for survival.
NF-kappa B genes have a major role in Inflammatory Breast Cancer
TLDR
The NF-κB pathway appears to play a major role in IBC, possibly contributing to the unusual phenotype and aggressiveness of this form of breast cancer.
Regulation of Ras-related RhoB protein expression during the cell cycle.
TLDR
It is reported here that RhoB is an unstable protein rapidly and transiently induced by growth factors in PC12 and HeLa cells and a vesicular and perinuclear localization of the endogenous RHoB protein induced bygrowth factors is confirmed.
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