Possible physiological roles of carboxylic ester hydrolases.
- F. Leinweber
- BiologyDrug metabolism reviews (Softcover ed.)
- 1987
(1987). Possible Physiological Roles of Carboxylic Ester Hydrolases. Drug Metabolism Reviews: Vol. 18, No. 4, pp. 379-439.
Metabolism of l‐bunolol
- F. J. D. Carlo, F. Leinweber, J. M. Szpiech, I. Davidson
- Chemistry, MedicineClinical pharmacology and therapy
- 1 December 1977
The metabolism of I‐bunolol, a new f3‐blocking drug, was studied in man after single oral 3‐mg doses of W‐labeled compound. Absorption from the gut was rapid and virtually complete. Peak levels of…
l-bunolol metabolites in human urine.
- F. Leinweber, J. M. Szpiech, F. Di Carlo
- Biology, ChemistryPharmacology
- 1978
Nine radiolabeled compounds were identified in human urine after administering a single oral dose of 3H-l-bunolol (3 mg) to 5 male volunteers, showing qualitative and quantitative differences from patterns observed in the rat and dog.
Drug disposition in the mammalian eye and brain: a comparison of mechanisms.
- F. Leinweber
- BiologyDrug metabolism reviews (Softcover ed.)
- 1991
The disposition and metabolic fate of 14C-cibenzoline in man.
- J. Massarella, A. Loh, F. Leinweber
- Medicine, BiologyDrug Metabolism And Disposition
- 1986
The disposition and metabolic fate of cibenzoline following single oral 153-mg doses of 14C-CBZ succinate were studied in five healthy adult males and several metabolites were identified in urine samples, none were found in substantial amounts relative to the parent drug.
Mechanism of histidine decarboxylase inhibition by NSD-1055 and related hydroxylamines.
- F. Leinweber
- Chemistry, BiologyMolecular Pharmacology
- 1 July 1968
The kinetics of inhibition by 4-bromo-3-hydroxybenzyloxyamine and several other O-substituted hydroxylamines were studied using partially purified histidine decarboxylase and oximes were prepared and shown to be effective competitive inhibitors with respect to the coenzyme.
Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol.
- F. Leinweber, R. Greenough, C. F. Schwender, H. R. Kaplan, F. Di Carlo
- Chemistry, BiologyXenobiotica; the fate of foreign compounds in…
- 1972
Synthetic dihydrobunolol was as active as bunolol in antagonizing isoproterenol-induced changes in blood pressure, heart rate and contractile force after intravenous administration to the dog.
Bunolol metabolism by human and rat red blood cells and extrahepatic tissues.
- F. Leinweber, F. Di Carlo
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 April 1974
In terms of the capacity of the total organ, only the red blood cell fraction and the liver appear to be significant sites of dihydrobunolol formation.
Isotopic determination of histidine decarboxylase: a disposable assay vial.
- F. Leinweber, L. Walker
- Biology, ChemistryAnalytical Biochemistry
- 1 October 1967
Microdetermination of cysteinesulfinic acid
- F. Leinweber, K. J. Monty
- Chemistry
- 1 September 1962
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