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The Mycobacterium tuberculosis PhoPR two‐component system regulates genes essential for virulence and complex lipid biosynthesis
TLDR
Functional evidence is provided for the PhoPR 2‐CS involvement in Mtb pathogenesis and it is suggested that a major reason for the attenuation observed in the phoP mutant is the absence of certain complex lipids that are known to be important for virulence. Expand
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.
TLDR
The complete 5.8-Mb genome sequence of M. ulcerans is reported and indicates that it has recently evolved via lateral gene transfer and reductive evolution from the generalist, more rapid-growing environmental species M. marinum to become a niche-adapted specialist. Expand
Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours.
TLDR
In patients suffering from lung cancer, plasma DNA as well as LDH and NSE represent cell death markers that are correlated with survival, at a time when apoptosis pathways appear to be potential targets for cancer therapy. Expand
Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy
TLDR
The kasB mutants exhibited strikingly altered cell wall permeability, leading to a marked increase in susceptibility to lipophilic antibiotics and the host antimicrobial molecules defensin and lysozyme, and are identified as a novel target for therapeutic intervention in mycobacterial diseases. Expand
Genomics of glycopeptidolipid biosynthesis in Mycobacterium abscessus and M. chelonae
TLDR
Although these three species produce identical GPL molecules, the organization of GPL genes differ between them, thus constituting species-specific signatures. Expand
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis
TLDR
It is proposed that LppX, a lipoprotein required for the translocation of complex lipids, the phthiocerol dimycocerosates (DIM), to the outer membrane of Mycobacterium tuberculosis, is the first characterized member of a family of structurally related lipoproteins that carry lipophilic molecules across the mycobacterial cell envelope. Expand
Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator
TLDR
It is shown by genetic transfer and virulence experiments that specific mutations in a virulence regulator contribute to lower fitness and virosity of M. bovis and related strains for the human host, likely obstructing the capacity of causing overt disease needed for efficient human-to-human transmission. Expand
Functional and phenotypic characterization of distinct porcine dendritic cells derived from peripheral blood monocytes
TLDR
Interestingly, and in contrast to the human and murine model, it was shown that the monocyte‐derived porcine Langerhans'‐type cells (MoLCs) were much more potent activators of allogeneic T cells than MoDCs obtained without TGF‐β1. Expand
Gap, a mycobacterial specific integral membrane protein, is required for glycolipid transport to the cell surface
TLDR
It is demonstrated that a small integral membrane protein of 272 amino acids named Gap (gap: GPL addressing protein) is specifically required for the transport of the GPLs to the cell surface, thus delineating a new protein family. Expand
Identification of the Polyketide Synthase Involved in the Biosynthesis of the Surface-Exposed Lipooligosaccharides in Mycobacteria
TLDR
It is shown that, in contrast to the case for "M. canettii" and M. marinum, LOS are located in deeper compartments of the cell envelope of M. smegmatis, and the availability of two mycobacterial strains differing only in LOS production should help in defining the biological role(s). Expand
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