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Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side.
It is shown that nodal regulates left-right asymmetry in the sea urchin but that, intriguingly, its expression is reversed compared to vertebrates. Expand
Patterning of the Dorsal-Ventral Axis in Echinoderms: Insights into the Evolution of the BMP-Chordin Signaling Network
Deciphering the process of dorsal-ventral patterning in the sea urchin reveals an extreme case of BMP translocation and an unusual configuration of the BMP-Chordin axis in echinoderms.
The Genome of the Sea Urchin Strongylocentrotus purpuratus
The sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus is reported, a model for developmental and systems biology and yields insights into the evolution of deuterostomes. Expand
Ancestral Regulatory Circuits Governing Ectoderm Patterning Downstream of Nodal and BMP2/4 Revealed by Gene Regulatory Network Analysis in an Echinoderm
A novel model for ectoderm regionalization is proposed, in which neural ectoderman is the default fate in the absence of TGF beta signaling, and it is suggested that the stomodeal and neural subcircuits that are uncovered may represent ancient regulatory pathways controlling embryonic patterning. Expand
Cis-regulatory analysis of nodal and maternal control of dorsal-ventral axis formation by Univin, a TGF-β related to Vg1
This work shows that Tcf, SoxB1 and Univin play essential roles in the regulation of nodal expression in the sea urchin and suggests that some of the regulatory interactions controlling nodalexpression predate the chordates. Expand
Nodal and BMP2/4 pattern the mesoderm and endoderm during development of the sea urchin embryo
It is confirmed that Nodal is a key regulator of dorsal-ventral polarity in the sea urchin and support the idea that the ventral ectoderm, like the Spemann organiser in vertebrates, is an organising centre that is required for patterning all three germ layers of the embryo. Expand
Lefty acts as an essential modulator of Nodal activity during sea urchin oral-aboral axis formation.
The expression pattern of lefty is described and its function in the process of secondary axis formation is analysed to suggest that Lefty acts as a long-range inhibitor of Nodal signalling in the sea urchin embryo. Expand
RTK and TGF-β signaling pathways genes in the sea urchin genome
The sea urchin complement of genes of the RTK and TGF-β signaling pathways is qualitatively very similar to the repertoire present in vertebrates, and that these genes are part of the common genetool kit for intercellular signaling of deuterostomes. Expand
A Transcriptomic-Phylogenomic Analysis of the Evolutionary Relationships of Flatworms
The phylogenetic analyses show that Platyhelminthes consist of the two clades Catenulida and Rhabditophora and identify Bothrioplanida as the long-sought closest free-living sister group of the parasitic Neodermata, and resolve Rhabdocoela as the most basally branching euneoophoran taxon. Expand
The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima
The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged, and concludes that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. Expand