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Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication.
TLDR
This work finds that anthranilic acid, the product of the PhnAB synthase, is the primary precursor of HAQs and that the HAQ congener 4-hydroxy-2-heptylquinoline (HHQ) is the direct precursor of the PQS signaling molecule.
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MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR‐class regulatory protein, has dual ligands
TLDR
It is shown that HHQ is highly produced in vivo, where it is not fully converted into PQS, and it is demonstrated that it is required for MvfR‐dependent gene expression and pathogenicity; PqS is fully dispensable, as pqsH– mutant cells, which produce HHQ but completely lack P QS, display normal Mv fR‐ dependent genes expression and virulence.
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rhlA is required for the production of a novel biosurfactant promoting swarming motility in Pseudomonas aeruginosa: 3-(3-hydroxyalkanoyloxy)alkanoic acids (HAAs), the precursors of rhamnolipids.
TLDR
Evidence is presented indicating that rhlA is required for production of HAAs and that these HAAs display potent surface-active properties, and it was shown that the use of ammonium instead of nitrate as source of nitrogen and an excess of available iron both decrease rhLA expression and swarming motility.
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Rhamnolipids: diversity of structures, microbial origins and roles
TLDR
A wide diversity of rhamnolipid congeners and homologues that are produced at different concentrations by various Pseudomonas species and by bacteria belonging to other families, classes, or even phyla are found.
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Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria
TLDR
The experiments link SR-mediated tolerance to reduced levels of oxidant stress in bacterial cells, and inactivating this protective mechanism sensitized biofilms by several orders of magnitude to four different classes of antibiotics and markedly enhanced the efficacy of antibiotic treatment in experimental infections.
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Production of rhamnolipids by Pseudomonas aeruginosa
TLDR
The rhamnolipids biosynthetic pathway has metabolic links with numerous bacterial products such as alginate, lipopolysaccharide, polyhydroxyalkanoates, and 4-hydroxy-2-alkylquinolines (HAQs).
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The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing‐regulated genes are modulated without affecting lasRI, rhlRI or the…
TLDR
Novel insights are provided into the unique role of the MvfR system in AHL‐mediated QS and further supports its importance in P. aeruginosa pathogenesis.
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Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa
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Liquid chromatography/mass spectrometry analysis of mixtures of rhamnolipids produced by Pseudomonas aeruginosa strain 57RP grown on mannitol or naphthalene.
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Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa
Opportunistic infections are often polymicrobial. Two of the most important bacterial opportunistic pathogens of humans, Pseudomonas aeruginosa and Staphylococcus aureus, frequently are coisolated…
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