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Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial
- A. Muacevic, B. Wowra, A. Siefert, J. Tonn, H. Steiger, F. Kreth
- Journal of Neuro-Oncology
- 1 May 2008
Background Is Gamma Knife surgery alone as effective as surgery plus whole brain irradiation (WBRT) for patients with a single, small-sized brain metastasis? Methods Patients aged between 18 and 80… Expand
Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis.
Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas
- E. Grasbon-Frodl, F. Kreth, +6 authors H. Kretzschmar
- International journal of cancer
- 1 December 2007
Hypermethylation of the DNA repair gene O6‐methyl‐guanine DNA methyltransferase (MGMT) has been linked to prolonged survival in glioblastoma patients treated with alkylating agents. It was aimed to… Expand
Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods?
- G. Poepperl, F. Kreth, +6 authors K. Tatsch
- Journal of nuclear medicine : official…
- 1 March 2006
UNLABELLED The aim of the present study was to evaluate whether extended analyses of O-(2-18F-fluoroethyl)-L-tyrosine (FET) uptake kinetics provide results superior to those of standard… Expand
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas
- J. Felsberg, N. Thon, +10 authors J. Tonn
- Biology, Medicine
- International journal of cancer
- 1 August 2011
Epigenetic silencing of the O6‐methylguanine‐DNA methyltransferase (MGMT) gene promoter is associated with prolonged survival in glioblastoma patients treated with temozolomide (TMZ). We investigated… Expand
Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5‐aminolevulinic acid induced protoporphyrin IX
Limited knowledge of the light and temperature distribution within the target volume in combination with non‐selective accumulation of the applied photosensitizers (PS) has hampered the clinical… Expand
MRI-suspected low-grade glioma: is there a need to perform dynamic FET PET?
- Nathalie Jansen, V. Graute, +8 authors C. Fougère
- European Journal of Nuclear Medicine and…
- 11 April 2012
PurposeSince differentiation between low-grade glioma (LGG) and high-grade glioma (HGG) remains challenging according to MRI criteria alone, we investigated the discriminative value of additional… Expand
The Risk of Haemorrhage after Image Guided Stereotactic Biopsy of Intra-Axial Brain Tumours – A Prospective Study
Summary Objective. To analyze prospectively the frequency and the risk of symptomatic and asymptomatic haemorrhage after image guided stereotactic biopsy of intra-axial brain tumours. Methods. The… Expand
The risk of interstitial radiotherapy of low-grade gliomas.
- F. Kreth, M. Faist, R. Roßner, W. Birg, B. Volk, C. Ostertag
- Radiotherapy and oncology : journal of the…
- 1 June 1997
BACKGROUND AND PURPOSE The risk of side effects of low activity (i.e. <20 mCi) Iodine-125I (125I) interstitial radiotherapy was analyzed in patients with low-grade gliomas. MATERIALS AND METHODS… Expand
Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter.
OBJECT The aim of this retrospective study was to compare treatment results of surgery plus whole-brain radiation therapy (WBRT) with gamma knife radiosurgery alone as the primary treatment for… Expand