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SAP-controlled T-B cell interactions underlie germinal centre formation
Generation of long-term antibody-mediated immunity depends on the germinal centre reaction, which requires cooperation between antigen-specific T and B lymphocytes. In human X-linkedExpand
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A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection
For acutely lethal influenza infections, the relative pathogenic contributions of direct viral damage to lung epithelium versus dysregulated immunity remain unresolved. Here, we take a top-downExpand
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Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
Osteoclasts are the only somatic cells with bone-resorbing capacity and, as such, they have a critical role not only in normal bone homeostasis (called ‘bone remodelling’) but also in theExpand
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Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
This corrects the article DOI: 10.1038/nature07713
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Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells
The lymph node follicular dendritic cell (FDC) network is derived from the expansion and differentiation of marginal reticular cells, as are the new FDCs generated during an immune response.
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Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions
Host defense against viruses and intracellular parasites depends on effector CD8(+) T cells, whose optimal clonal expansion, differentiation, and memory properties require signals from CD4(+) TExpand
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Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naïve CD4+ and CD8+ T cells
Naïve T cells continually recirculate between blood and secondary lymphoid organs, scanning dendritic cells (DC) for foreign antigen. Despite its importance for understanding how adaptive immuneExpand
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Computational Modeling of Cellular Signaling Processes Embedded into Dynamic Spatial Contexts
Cellular signaling processes depend on spatiotemporal distributions of molecular components. Multicolor, high-resolution microscopy permits detailed assessment of such distributions, providing inputExpand
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Multicolor fate mapping of Langerhans cell homeostasis
The adult epidermal Langerhans cell network is formed by adjacent proliferative units composed of dividing cells and their terminally differentiated daughter cells.
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Prognostic impact of tumour-infiltrating immune cells on biliary tract cancer
Background:Biliary tract cancers (BTC) are relatively rare malignant tumours with poor prognosis. It is known from other solid neoplasms that antitumour inflammatory response has an impact on tumourExpand
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