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Mn and Mg influxes through Ca channels of motor nerve terminals are prevented by verapamil in frogs
At frog neuromuscular junctions immersed in solutions containing 0.5 mM Mn2+, verapamil (40 microM) reduced the increase in miniature end-plate potential (MEPP) frequency produced by tetanic… Expand
Apolipoprotein E genetic polymorphism, remnant lipoproteins, and nephropathy in type 2 diabetic patients.
BACKGROUND We previously showed that the apolipoprotein (apo) Eepsilon2 allele is associated with the progression of diabetic nephropathy. The aim of the present study is to further investigate the… Expand
Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice.
- F. Kawasaki, M. Matsuda, Y. Kanda, H. Inoue, K. Kaku
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 1 March 2005
To evaluate preventive effects of pioglitazone on pancreatic beta-cell damage in C57BL/KsJ db/db mice, an obese diabetic animal model, the pancreatic islets were compared morphologically between… Expand
Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects
- M. Matsuda, F. Kawasaki, +5 authors K. Kaku
- Diabetic medicine : a journal of the British…
- 1 August 2004
Aims Adipocytokines, products from adipose tissue, have biological activities on the vascular system, and may affect diabetic angiopathy. In this study, we assessed the relationship between… Expand
Rescue of beta-cell exhaustion by diazoxide after the development of diabetes mellitus in rats with streptozotocin-induced diabetes.
In this study, we attempted to demonstrate the possibility of rescuing beta-cell exhaustion by chronic intervention with an ATP-sensitive K(+) channel opener, diazoxide, which reduces the stress of… Expand
Structure and innervation of longitudinal and transverse abdominal muscles of the cricket, gryllus bimaculatus
Detailed morphological and physiological studies on the insect abdominal muscles, including their innervation and neuromuscular transmission, are essential for understanding their important role in… Expand
MIN6 is not a pure beta cell line but a mixed cell line with other pancreatic endocrine hormones.
- K. Nakashima, Y. Kanda, Y. Hirokawa, F. Kawasaki, M. Matsuki, K. Kaku
- Biology, Medicine
- Endocrine journal
- 1 February 2009
MIN6 cells retains glucose-stimulated insulin secretion (GSIS) as isolated islets. We comprehensively evaluated the gene expression and production of other islet hormones in MIN6 cells. Islet… Expand
Analysis of waist circumference in Japanese subjects with type 2 diabetes mellitus: lack of propriety to define the current criteria of metabolic syndrome.
- Y. Kanda, M. Matsuda, +4 authors K. Kaku
- Diabetes research and clinical practice
- 1 September 2007
A necessary condition of advocated criteria to determine the metabolic syndrome (MetS) in Japan is waist circumference (WC), which varies among races. In this study, we measured WC and visceral fat… Expand
Effect of apolipoprotein E4 allele on plasma LDL cholesterol response to diet therapy in type 2 diabetic patients.
OBJECTIVE The aim of this study was to investigate the effect of apolipoprotein (apo)E4 allele on plasma LDL cholesterol response to calorie-restricted diet therapy in type 2 diabetic patients. … Expand
Pharmacokinetics and pharmacodynamics of glimepiride in type 2 diabetic patients: compared effects of once- versus twice-daily dosing.
To compare the pharmacokinetic and pharmacodynamic effects of glimepiride between once- and twice-daily dosing in type 2 diabetic patients. Eight Japanese type 2 diabetic patients, who had been… Expand