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A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon.
Northern blot analyses with the mGluR5b-specific probe showed that the expression of mRNA for this species is regulated in a region-specific manner in the rat brain.
Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.
- R. Minakami, F. Katsuki, T. Yamamoto, K. Nakamura, H. Sugiyama
- BiologyBiochemical and biophysical research…
- 30 March 1994
It is shown that the glutamate-evoked responses appear in Xenopus oocytes while expressing either of the two mGluR5 isoforms, which suggests that these two receptors from the human brain could activate phospholipase C and generate Ca(2+)-activated Cl- current.