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A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. We mapped FOP to chromosome 2q23-24 by linkageExpand
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Conversion of vascular endothelial cells into multipotent stem-like cells
Mesenchymal stem cells can give rise to several cell types, but varying results depending on isolation methods and tissue source have led to controversies about their usefulness in clinical medicine.Expand
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Bone Formation and Inflammation in Cardiac Valves
BackgroundFor nearly a century, the mechanical failure of calcified heart valves was attributed to a passive degenerative process. Recently, several case reports described bone formation inExpand
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Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1
Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant human disorder of bone formation that causes developmental skeletal defects and extensive debilitating bone formation within softExpand
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Identification of progenitor cells that contribute to heterotopic skeletogenesis.
BACKGROUND Individuals who have fibrodysplasia ossificans progressiva develop an ectopic skeleton because of genetic dysregulation of bone morphogenetic protein (BMP) signaling in the presence ofExpand
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Prevention and management of osteoporosis.
The importance of osteoporosis as a health problem in the United States was underscored by the enthusiastic reception given to the two previous Clinical Symposia (1983 and 1987) written by FrederickExpand
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Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia.
BACKGROUND Progressive osseous heteroplasia (POH), an autosomal dominant disorder, is characterized by extensive dermal ossification during childhood, followed by disabling and widespread heterotopicExpand
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Fibrodysplasia Ossificans Progressiva: Clinical and Genetic Aspects
Fibrodysplasia ossificans progressiva (FOP) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopicExpand
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Treatment of Osteoporosis: Are Physicians Missing an Opportunity?*†
Background: Medical treatment of women with established osteoporosis may decrease the incidence of future fractures. Postmenopausal women who have sustained a distal radial fracture have decreasedExpand
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Inherited human diseases of heterotopic bone formation
Human disorders of hereditary and nonhereditary heterotopic ossification are conditions in which osteogenesis occurs outside of the skeleton, within soft tissues of the body. The resultingExpand
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