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A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. We mapped FOP to chromosome 2q23-24 by linkage… Expand
Conversion of vascular endothelial cells into multipotent stem-like cells
Mesenchymal stem cells can give rise to several cell types, but varying results depending on isolation methods and tissue source have led to controversies about their usefulness in clinical medicine.… Expand
Bone Formation and Inflammation in Cardiac Valves
- E. Mohler, F. Gannon, C. Reynolds, R. Zimmerman, M. Keane, F. Kaplan
- Medicine
- Circulation
- 20 March 2001
BackgroundFor nearly a century, the mechanical failure of calcified heart valves was attributed to a passive degenerative process. Recently, several case reports described bone formation in… Expand
Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1
Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant human disorder of bone formation that causes developmental skeletal defects and extensive debilitating bone formation within soft… Expand
Identification of progenitor cells that contribute to heterotopic skeletogenesis.
- V. Lounev, R. Ramachandran, +6 authors F. Kaplan
- Medicine
- The Journal of bone and joint surgery. American…
- 1 March 2009
BACKGROUND
Individuals who have fibrodysplasia ossificans progressiva develop an ectopic skeleton because of genetic dysregulation of bone morphogenetic protein (BMP) signaling in the presence of… Expand
Prevention and management of osteoporosis.
- F. Kaplan
- Medicine
- Clinical symposia
- 1995
The importance of osteoporosis as a health problem in the United States was underscored by the enthusiastic reception given to the two previous Clinical Symposia (1983 and 1987) written by Frederick… Expand
Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia.
- E. Shore, J. Ahn, +7 authors F. Kaplan
- Biology, Medicine
- The New England journal of medicine
- 10 January 2002
BACKGROUND
Progressive osseous heteroplasia (POH), an autosomal dominant disorder, is characterized by extensive dermal ossification during childhood, followed by disabling and widespread heterotopic… Expand
Fibrodysplasia Ossificans Progressiva: Clinical and Genetic Aspects
- R. Pignolo, E. Shore, F. Kaplan
- Medicine
- Orphanet journal of rare diseases
- 1 December 2011
Fibrodysplasia ossificans progressiva (FOP) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic… Expand
Treatment of Osteoporosis: Are Physicians Missing an Opportunity?*†
- K. Freedman, F. Kaplan, W. Bilker, B. Strom, R. Lowe
- Medicine
- The Journal of bone and joint surgery. American…
- 1 August 2000
Background: Medical treatment of women with established osteoporosis may decrease the incidence of future fractures. Postmenopausal women who have sustained a distal radial fracture have decreased… Expand
Inherited human diseases of heterotopic bone formation
Human disorders of hereditary and nonhereditary heterotopic ossification are conditions in which osteogenesis occurs outside of the skeleton, within soft tissues of the body. The resulting… Expand