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The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absorption through a paracellular pathway.
TLDR
Results supported that, as shown in the in vitro Caco-2 cell system, the C10 effect on the paracellular pathway is due to activating the contraction of Ca(2+)-calmodulin-dependent actin filament.
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Enhancing effects of myristyl lactate and lauryl lactate on percutaneous absorption of indomethacin in rats.
TLDR
It was suggested that ML acts on the stratum corneum to produce its effect as an enhancer and was observed to be markedly enhanced by the addition of ML or LL to PG as compared with the control (PG alone).
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Enantiomeric difference in percutaneous penetration of propranolol through rat excised skin.
TLDR
The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro and it is suggested that there is an enantiomeric difference between S- and R- in terms of penetration through rat stratum corneum.
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Percutaneous absorption of indomethacin from mixtures of fatty alcohol and propylene glycol (FAPG bases) through rat skin: effects of oleic acid added to FAPG base.
TLDR
If FAPG base is to be used as a vehicle for the purpose of percutaneous absorption of ID, OA is considered to be a useful additive because it was observed that when OA was added to the vehicles in the range of 5 to 30%, the per cutaneous absorption from the vehicles was increased.
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Improvement of drug release rate from carbopol 934P formulation.
TLDR
Freeze-dried sodium salt of CP improves the drug release rate from the solid CP formulation, it could be a useful adjuvant of an oral bioadhesive drug delivery system.
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Use of sodium salt of Carbopol 934P in oral peptide delivery
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Effect of phosphatidylcholine and cholesterol on pH-sensitive liposomes.
TLDR
It was shown that pH-sensitivity can be controlled by addition of the appropriate amount of PC and/or Chol to liposomal lipids, and that aggregation or fusion of liposomes causes the leakage.
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Enhancing effect of cetyl lactate on the percutaneous absorption of indomethacin in rats.
TLDR
It was confirmed that CL acts on the stratum corneum to produce its effect and marked enhancing effects on percutaneous absorption of ID were obtained at a concentration greater than 1% CL in PG.
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Disintegration and gel forming behaviour of carbomer and its sodium salt used as excipients for direct compression
Les polymeres d'acide polyacrylique, tels que le carbomer (Carbopol 934P, C934P) et son sel de sodium (Carbopol EX-161, NaC934P), ont ete etudies en tant qu'excipients pour compression directe, dans…
Analysis of Adverse Reaction in Kampo-Medicines Using JADER Database of PMDA
TLDR
This study analyzed adverse drug events of kampo-medicines using Japanese Adverse Drug Event Report (JADER) database of PMDA and found the largest number of reports was on Shakuyakukanzoto, followed in order by Bofutsushosan,Saireito and Yokukansan.
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