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Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons.
  • F. Jongeneelen
  • Medicine, Chemistry
  • The Annals of occupational hygiene
  • 2001
Many individual polycyclic aromatic hydrocarbons (PAH) are genotoxic carcinogens. One of the parent PAH, pyrene, undergoes simple metabolism to 1-hydroxypyrene. 1-Hydroxypyrene and its glucuronideExpand
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Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urine.
9,101, show excess rates of lung cancers. Estimates of the health risks due to environmental or occupational exposure to these compounds strongly depend on the quality of analytical methods used toExpand
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Biological exposure limit for occupational exposure to coal tar pitch volatiles at cokeovens
  • F. Jongeneelen
  • Chemistry, Medicine
  • International archives of occupational and…
  • 1992
SummaryBiological monitoring is an efficient tool in the evaluation of exposure to chemical agents. However, the dose-response of adverse health effects using biological exposure indices andExpand
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A guidance value of 1-hydroxypyrene in urine in view of acceptable occupational exposure to polycyclic aromatic hydrocarbons.
Occupational exposure limits for carcinogens are increasingly based on excess lifetime risks of cancer. Acceptable limits in some countries in Europe are set at 4/1000 (=highest tolerable risk level)Expand
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Airborne concentrations, skin contamination, and urinary metabolite excretion of polycyclic aromatic hydrocarbons among paving workers exposed to coal tar derived road tars.
The exposure of surface dressing workers to polycyclic aromatic hydrocarbons (PAH) was studied. Four different paving sites, at which coal tar-containing binders were applied, were selected as workExpand
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Estimation of individual dermal and respiratory uptake of polycyclic aromatic hydrocarbons in 12 coke oven workers.
Twelve workers from a coke plant in The Netherlands participated in an intensive skin monitoring programme combined with personal air sampling and biological monitoring during five consecutive eightExpand
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Ambient and biological monitoring of cokeoven workers: determinants of the internal dose of polycyclic aromatic hydrocarbons.
Polycyclic aromatic hydrocarbons (PAH) were measured in the breathing zone air of 56 battery workers at two cokeovens during three consecutive days. The concentration of total PAH ranged up to 186Expand
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Smoking and dietary intake of polycyclic aromatic hydrocarbons as sources of interindividual variability in the baseline excretion of 1-hydroxypyrene in urine
SummarySeventy-six male volunteers, who were not occupationally exposed to polycyclic aromatic hydrocarbons (PAHs), participated in a study on the effect of tobacco smoking, alcohol consumption,Expand
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The relationship between polycyclic aromatic hydrocarbons in air and in urine of workers in a Söderberg potroom.
The relationships between increase of urinary 1-hydroxypyrene over the workweek and the airborne concentrations of benzo(a)pyrene and coal tar pitch volatiles (CTPVs) were studied among groups ofExpand
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