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Subchronic inhalation toxicity of hexamethylenediamine in rats.
Four groups of 15 male and 15 female Sprague-Dawley-derived (CD) rats each were exposed to aqueous hexamethylenediamine (HMD) aerosols for 6 hr/day, 5 days/week for 13 weeks at mean analytical
Evaluation of delayed neurotoxicity and dose-response relationships of phosphate esters in the adult hen.
An oral multipledose technique in hens was developed to determine the neurotoxic potential of a series of triaryl-, trialkyl-, and alkyl-aryl phosphates, and conclusions regarding structure-activity relationships may be drawn.
A Review of the Subchronic Toxicity of Butyl Benzyl Phthalate
BBP-induced toxicity occurs only at relatively high levels of exposure and is dependent on the species, age and strain of test animals used, which should be considered in extrapolating findings from animal toxicology studies to humans when assessing the safety of BBP.
Evaluation of the subchronic and reproductive effects of a series of chlorinated propanes in the rat. I. Toxicity of 1,2,3-trichloropropane.
Repeated inhalation exposure and 1-generation reproduction studies have been conducted in the rat to address the adequacy of the 10 ppm occupational exposure limit established for
A scheme for classifying carcinogens.
This work identifies the kinds of information that can be useful in this process, and indicates how each might most appropriately be used in the classification of chemical carcinogens.
Assessment of the Delayed Neurotoxicity of Tributyl Phosphate, Tributoxyethyl Phosphate, and Dibutylphenyl Phosphate
Results indicate that TBP, TBEP, and DBPP are all unlikely to cause OPIDN with any single sublethal dose.
Toxicological profile of orally administered 1,6‐hexane diamine in the rat
Dietary administration of HMD to groups of rats for 3 months at dosages of 0, 50, 150, and 500 mg kg−1 resulted in a modest retardation in weight gain at the two higher test levels, but there were no other obvious signs of toxicity or changes in the peripheral blood picture or selected clinical pathology parameters during the study.
Toxicological profile of carboxymethyl inulin.
  • F. Johannsen
  • Chemistry, Medicine
    Food and chemical toxicology : an international…
  • 2003
Lack of adverse toxicity seen with CMI at this dosage is consistent with a similar lack of significant toxicity exhibited by other dietary carbohydrates in repeated-dose rat studies at approximately the same dosage.
Evaluation of the teratogenic potential of three aliphatic nitriles in the rat.
Embryotoxic effects were observed at the highest dosage tested for ACN and middle and high dose levels for PN, and no teratogenic effects were observation at any dosage level with ACN, ADN, or PN.
Risk assessment of carcinogenic and noncarcinogenic chemicals.
Quantitative Risk Assessment methods using mathematical models have been advanced to extrapolate from animal exposures which are usually high to much lower human exposure levels where experimental response is absent, and the present manuscript considers both methods for evaluation of chemical safety.