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Stereoselective pharmacokinetics of flurbiprofen in humans and rats.
TLDR
The pharmacokinetics of flurbiprofen enantiomers following single doses were studied in humans and rats and the observed stereoselectivity in humans cannot be attributed to enantiomeric bioinversion, as S-flurbip rofen was not detected in plasma and urine after oral administration of R-flurin.
Pharmacokinetics of celecoxib in the presence and absence of interferon-induced acute inflammation in the rat: application of a novel HPLC assay.
TLDR
An HPLC assay for CEL was developed and validated and demonstrated sufficient accuracy and precision for pharmacokinetic studies of CEL in the rat, although a trend towards increased plasma concentration was noticed.
Influence of Host Plant Genotype, Presence of a Pathogen, and Coinoculation with Pseudomonas fluorescens Strains on the Rhizosphere Expression of Hydrogen Cyanide- and 2,4-Diacetylphloroglucinol
TLDR
This is the first study investigating the impact of biotic factors on HCN production by a bacterial biocontrol strain in the rhizosphere and observing a several-fold higher expression in theRhizosphere of cv.
Biological control of chickpea Fusarium wilt by antagonistic bacteria under greenhouse condition.
TLDR
In this survey, Fusarium oxysporum was isolated from roots infected plants and was shown to be pathogenic, and use of antagonists in combination had no significant effect on plant growth factors and reduction wilt disease.
Presystemic and systemic chiral inversion of R-(-)-fenoprofen in the rat.
TLDR
The results indicate that, in the male Sprague-Dawley rat, R-FN undergoes presystemic inversion by both the gastrointestinal tract and liver, and must be viewed with caution as they may not necessarily be extrapolated to other 2-APAs or species.
Drug‐disease interactions: reduced β‐adrenergic and potassium channel antagonist activities of sotalol in the presence of acute and chronic inflammatory conditions in the rat
TLDR
The reduced electrocardiographic responses to sotalol is likely due to the influence of inflammation on the action of the drug on both β‐adrenergic and potassium channel receptors secondary to over‐expression of pro‐inflammatory cytokines and/or nitric oxide.
Evidence of absorption rate dependency of ibuprofen inversion in the rat.
TLDR
In the rat, the S:R AUC ratio was positively and significantly correlated with the absorption rate from the dosage form, and AUCS and AUCR significantly increased and decreased after administration of the sustained released granules as compared with the solution and suspension.
Enantiomeric interaction of flurbiprofen in the rat.
TLDR
While the enantiomeric interaction caused a significant enlargement of the volume of distribution of R-FL, it failed to alter the terminal half-life of the en Anti-inflammatory drug, Flurbiprofen.
Pharmacokinetics of tiaprofenic acid in healthy and arthritic subjects.
TLDR
The pharmacokinetics of tiaprofenic acid in arthritic patients seems to be similar to those in healthy subjects and under treatment with 200 mg of the drug three times daily.
High performance liquid chromatographic determination of cyclooxygenase II inhibitor rofecoxib in rat and human plasma.
  • F. Jamali, S. Sattari
  • Chemistry
    Journal of pharmacy & pharmaceutical sciences : a…
  • 1 September 2000
TLDR
A new assay for determination of rofecoxib is developed that is convenient, sensitive, and simple, suitable to pharmacokinetic studies of the drug in rats and humans.
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