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Neuroinflammation: friend and foe for ischemic stroke
How neuroinflammation has both beneficial as well as detrimental roles and recent therapeutic strategies to combat pathological responses are discussed and the time-dependent role of inflammatory factors could help in developing new diagnostic, prognostic, and therapeutic neuroprotective strategies for post-stroke inflammation. Expand
Hypoxia-Induced Neuroinflammatory White-Matter Injury Reduced by Minocycline in SHR/SP
It is proposed that BBB disruption occurred secondary to hypoxia, which induced an MMP-9-mediated infiltration of leukocytes, and minocycline significantly reduced WM damage, improved behavior, and prolonged life. Expand
Myelin Loss Associated With Neuroinflammation in Hypertensive Rats
Investigating the role of neuroinflammation in white matter damage in spontaneously hypertensive stroke-prone rats found apoptosis of mature Ols with an increase in immature Ols, and increased MMP-3, M MP-9, and tumor necrosis factor-&agr; were associated with myelin breakdown and BBB disruption. Expand
Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases
Recent preclinical as well as clinical results that support the relevance of H3R antagonists for the treatment of cognitive symptoms in neuropsychiatric diseases, namely AD, epilepsy and SCH are focused on. Expand
Acetyl‐l‐carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats
To determine ALCAR's neuroprotective effects, focal cerebral ischemia was induced using four models of middle cerebral artery occlusion (MCAO) and treatment with 0–400 mg/kg ALCar (i.p.) prior to MCAO, and acute doses were without effect. Expand
The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism
Modulation of brain histaminergic neurotransmission, such as by subchronic administration of the H3R antagonist DL77, may serve as an effective pharmacological therapeutic target to rescue ASD-like behaviors in VPA-exposed animals, although further investigations are necessary to corroborate and expand these initial data. Expand
Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice
  • Yi Yang, F. Jalal, +8 authors G. Rosenberg
  • Biology, Medicine
  • Journal of Neuroinflammation
  • 29 August 2011
It is suggested that focal ischemia leads to proliferation of immature OLs in white matter and that TIMP-3 contributes to a caspase-3-dependent immature OL death via TNF-α-mediated neuroinflammation. Expand
Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury
It is proposed that chronic hypoxia disrupts TJPs, increasing vascular permeability, and initiating angiogenesis in WM, which facilitates WM repair by reducing BBB damage and enhancing expression of TJPs andAngiogenesis, ultimately preserving oligodendrocytes. Expand
Tissue Oxygen is Reduced in White Matter of Spontaneously Hypertensive-Stroke Prone Rats: A Longitudinal Study with Electron Paramagnetic Resonance
It is suggested that changes in WM pO2 may contribute to WM damage in SHR/SP rat model, and that EPR oximetry can monitor brain pO1 in the WM of small animals. Expand
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease
Robtenone-injected rats that were orally treated with lycopodium were protected against dopaminergic neuronal loss by diminishing the expression of matrix metalloproteinase-3 and MMP-3, as well as reduced activation of microglia and astrocytes, suggesting that Lyc has the potential to be further developed as a therapeutic candidate for PD. Expand