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Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis
TLDR
The aim of this review is to recapitulate the clinical understanding of CSCR, with an emphasis on the most recent findings on epidemiology, risk factors, clinical and imaging diagnosis, and treatments options, and the novel mineralocorticoid pathway hypothesis. Expand
Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.
TLDR
The results identify MR signaling as a pathway controlling choroidal vascular bed relaxation and provide a pathogenic link with human CSCR, which suggests that blockade of MR could be used therapeutically to reverse choroid vasculopathy. Expand
Conditional Mineralocorticoid Receptor Expression in the Heart Leads to Life-Threatening Arrhythmias
TLDR
Cardiac MR overexpression led to ion channel remodeling, resulting in prolonged ventricular repolarization at both the cellular and integrated levels and in severe ventricular arrhythmias, suggesting novel opportunities for prevention of arrhythmia-related sudden death. Expand
Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation.
TLDR
To identify the phosphorylation sites, the alpha 1-subunit of Bufo marinus is mutated in a highly conservative PKA and in 20 different PKC consensus sequences and serine 943 (Ser-943) was identified as a unique target site for PKA, but none of thePKC consensus serine or threonine residues are implicated in PKC phosphorylated residues. Expand
Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response.
TLDR
Cross-talk between the nongenomic and genomic responses to aldosterone in renal cells is suggested and it is suggested that the ald testosterone-MR mediated increase in mRNA/protein synthesis and ion transport depends, at least in part, upon PKCalpha activation. Expand
The Rat Distal Colon P-ATPase Subunit Encodes a Ouabain-sensitive H,K-ATPase (*)
TLDR
It is concluded that, when expressed in Xenopus oocytes, the rat colon P-ATPase α subunit encodes a ouabain-sensitive H,K-atPase, and that co-expression of α and β subunits is required for the function. Expand
Regulatory Sequences of the Mouse Villin Gene That Efficiently Drive Transgenic Expression in Immature and Differentiated Epithelial Cells of Small and Large Intestines*
TLDR
The 9-kb genomic region contains the necessary cis-acting elements to recapitulate the tissue-specific expression pattern of the endogenous villin gene and can be used to target heterologous genes in immature and differentiated epithelial cells of the small and/or large intestinal mucosa. Expand
The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure
TLDR
It is demonstrated that enhanced MR activation in the endothelium generates an increase in blood pressure, independent of stimulation of renal tubular Na+ transport by aldo/MR or direct activation of smooth muscle MR, and establish one mechanism by which endothelial MR activation per se may contribute to impaired vascular reactivity. Expand
In Vivo, Villin Is Required for Ca2+-Dependent F-Actin Disruption in Intestinal Brush Borders
TLDR
The results suggest that in vivo, villin is not necessary for the bundling of F-actin microfilaments, whereas it is needed for the reorganization elicited by various signals. Expand
Prevention of liver cancer cachexia-induced cardiac wasting and heart failure.
TLDR
Systemic effects of tumours lead not only to CC but also to cardiac wasting, associated with LV-dysfunction, fibrotic remodelling, and increased mortality, which can be mitigated by treatment with either the β-blocker bisoprolol or the aldosterone antagonist spironolactone. Expand
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