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Inhibition of protein phosphatases‐1 and ‐2A with acanthifolicin
TLDR
Pure acanthifolicin/okadaic acid methyl ester may be useful as specific inhibitors of PP2A at 1–10 μM concentrations in vitro and perhaps in vivo and indicate that a region on these toxins important for PP1/2A inhibition comprises the single carboxyl group. Expand
Inhibition of Protein Phosphatase-1 by Clavosines A and B
TLDR
The mutagenesis results suggest that a hydrogen bond between Tyr-134 and the calyculins is unlikely to be essential for inhibitor binding to the phosphatase, and a new model for clavosine andCalyculin A binding to PP-1c is presented that is consistent with previous structure-function experiments and which accommodates key structural features of theclavosines. Expand
Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyl transferase inhibitor Etomoxir.
TLDR
Etomoxir may be valuable not only as a potential anti-diabetic drug but also as a lipid-lowering agent for the treatment of diabetic related dyslipoproteinaemias and, in addition, as an agent in the Treatment of diabetic cardiomyopathy. Expand
A new pathway of tumor promotion by the okadaic acid class compounds.
Influence of carnitine acyltransferase inhibitors on the performance and metabolism of rat cardiac muscle.
TLDR
Carnitine palmitoyl transferase inhibitors have clear antidiabetic effects, but before using as an oral antidi diabetic drug, the long-term changes of the lipid and carnitine metabolism should be evaluated. Expand