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Hb D-Los Angeles associated with Hb S or beta-thalassemia in four Mexican Mestizo families.
Hb D is clinically harmful when it is associated with Hb S, and the true origin of this mutation observed in these Mestizo families remains to be elucidated.
Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings.
Red cell membrane protein deficiencies in Mexican patients with hereditary spherocytosis.
β-Thalassemia and βA globin gene haplotypes in Mexican mestizos
Analysis of the rare alleles showed that the –28 A→C mutation was associated with the commonest βA haplotype in Mexican mestizos, Mediterraneans and the total world population; therefore an independent origin cannot be ruled out.
HLA-DQB1, -DQA1, -DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara, Mexico.
Three-locus genotype data from all family members were used to infer haplotypes in 54 unrelated individuals of the sample, from which estimate of segregating haplotype frequencies and linkage disequilibrium (LD) between loci were computed.
Analysis of betaS and betaA genes in a Mexican population with African roots.
The data suggest distinct origins for the beta(A) and beta(S) genes in Mexican individuals from the Costa Chica region, and suggest a high similitude with the population of the Central African Republic.
Centromere–telomere (12;8p) fusion, telomeric 12q translocation, and i(12p) trisomy 1
FISH findings suggest that the prime event was a post‐fertilization centric fission of chromosome 12 leading to the 12q translocation via a real centromere–telomere fusion and the i(12p), Alternatively, the crucial event may have been a centronere– telomere recombination.
Hemoglobin D-Los Angeles (Btha 121 Glu-Gln) in a mexican family
Diversity of the 5′ β-Globin Haplotype of Four β-Thalassemia Mutations in the Mexican Population
Molecular analyses revealed the presence of 17 β-thal mutations in the Mexican population; the most frequent of these are the nonsense codon 39 (C>T), IVS-I-1 (G>A), IVE-110 (G >A), and −28 (A>C), and to improve knowledge about their origin, the 5′ haplotypes by restriction fragment length polymorphism were analyzed.
Analysis of βS and βA Genes in a Mexican Population with African Roots
The data suggest distinct origins for the β A and β S genes in Mexican individuals from the Costa Chica region, which is more closely related to those of Mexican Mestizos and North Africans.