Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
- Smriti M. Agrawal, P. Anderson, L. Sorokin
- BiologyJournal of Experimental Medicine
- 17 April 2006
It is shown here that macrophage-derived gelatinase (matrix metalloproteinase [MMP]-2 and MMP-9) activity is crucial for leukocytes penetration of the parenchymal BM, the first description of selective in situ proteolytic damage of a BBB-specific molecule at sites of leukocyte infiltration.
CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells
- L. Cederbom, H. Hall, F. Ivars
- Biology, MedicineEuropean Journal of Immunology
- 1 June 2000
It is found that CD4+CD25+ T cells down‐regulated the expression of the co‐stimulatory molecules CD80 and CD86 on dendritic cells, suggesting that distinct mechanisms regulate theexpression of these molecules.
Cytotoxic T lymphocyte antigen‐4‐dependent down‐modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T‐cell‐mediated suppression
- C. Oderup, L. Cederbom, A. Makowska, C. Cilio, F. Ivars
- BiologyImmunology
- 1 June 2006
It is proposed that Treg cells down‐modulate B7‐molecules on DCs in a CTLA‐4‐dependent way, thereby enhancing suppression of T‐cell activity.
Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides
- P. Björk, A. Björk, T. Leanderson
- Biology, ChemistryPLoS Biology
- 1 April 2009
The specific binding of quinoline-3-carboxamides to S100A9 explains the immunomodulatory activity of this class of compounds and defines S 100A9 as a novel target for treatment of human autoimmune diseases.
Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain
- Chuan Wu, F. Ivars, L. Sorokin
- Biology, MedicineNature Network Boston
- 1 May 2009
It is shown that targeting lymphocyte interactions with endothelial basement membrane laminins provides a means of inhibiting disease without compromising innate immune responses, and that T lymphocytes use mechanisms distinct from other immune cells to penetrate the endothelium basement membrane barrier.
S100A9 Interaction with TLR4 Promotes Tumor Growth
- E. Källberg, T. Vogl, T. Leanderson
- BiologyPLoS ONE
- 28 March 2012
S 100A9 and TLR4 appear to be involved in promoting tumor growth in two different tumor models and pharmacological inhibition of S100A9-TLR4 interactions is a novel and promising target for anti-tumor therapies.
An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.
- C. Åkesson, H. Lindgren, R. Pero, T. Leanderson, F. Ivars
- BiologyInternational Immunopharmacology
- 1 December 2003
Transforming growth factor-beta- and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis.
- A. Rosendahl, M. Speletas, K. Leandersson, F. Ivars, P. Sideras
- BiologyInternational Immunology
- 1 December 2003
The functional experiments in vitro suggest that members of the TGF-beta family (TGF- beta or Activin) may play important non-redundant roles during different stages of thymopoiesis.
Induction of nuclear factor‐κB responses by the S100A9 protein is Toll‐like receptor‐4‐dependent
- M. Riva, E. Källberg, T. Leanderson
- BiologyImmunology
- 1 October 2012
The data indicate that both human and mouse S100A9 are TLR4 agonists, and induced stronger NF‐κB activation albeit weaker cytokine secretion than LPS, suggesting that S 100A9 and LPS activated NF‐kkB in a qualitatively distinct manner.
C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo.
- C. Åkesson, R. Pero, F. Ivars
- Medicine, BiologyPhytomedicine
- 2003
Accumulation is concluded that accumulation is most likely due to prolonged cell survival, because adoptive transfer experiments demonstrated that C-Med 100 treatment significantly prolonged lymphocyte survival in peripheral lymphoid organs, without increasing their proliferation rate.
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