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CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells
TLDR
It is found that CD4+CD25+ T cells down‐regulated the expression of the co‐stimulatory molecules CD80 and CD86 on dendritic cells, suggesting that distinct mechanisms regulate theexpression of these molecules.
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
TLDR
It is shown here that macrophage-derived gelatinase (matrix metalloproteinase [MMP]-2 and MMP-9) activity is crucial for leukocytes penetration of the parenchymal BM, the first description of selective in situ proteolytic damage of a BBB-specific molecule at sites of leukocyte infiltration.
Cytotoxic T lymphocyte antigen‐4‐dependent down‐modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T‐cell‐mediated suppression
TLDR
It is proposed that Treg cells down‐modulate B7‐molecules on DCs in a CTLA‐4‐dependent way, thereby enhancing suppression of T‐cell activity.
Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides
TLDR
The specific binding of quinoline-3-carboxamides to S100A9 explains the immunomodulatory activity of this class of compounds and defines S 100A9 as a novel target for treatment of human autoimmune diseases.
Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain
TLDR
It is shown that targeting lymphocyte interactions with endothelial basement membrane laminins provides a means of inhibiting disease without compromising innate immune responses, and that T lymphocytes use mechanisms distinct from other immune cells to penetrate the endothelium basement membrane barrier.
S100A9 Interaction with TLR4 Promotes Tumor Growth
TLDR
S 100A9 and TLR4 appear to be involved in promoting tumor growth in two different tumor models and pharmacological inhibition of S100A9-TLR4 interactions is a novel and promising target for anti-tumor therapies.
An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.
TLDR
It is confirmed that C-Med 100, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency and it is proposed that retarded cell cycle progression caused the inhibition of proliferation.
Transforming growth factor-beta- and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis.
TLDR
The functional experiments in vitro suggest that members of the TGF-beta family (TGF- beta or Activin) may play important non-redundant roles during different stages of thymopoiesis.
Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100.
TLDR
It is reported that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100 exposure.
Common Interactions between S100A4 and S100A9 Defined by a Novel Chemical Probe
TLDR
It is shown that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced glycation end-products (RAGE) interacts with both S100 a9 and S 100A4; interactions that can be inhibited by OX.
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