• Publications
  • Influence
Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells
The effect of hepatocyte growth factor /scatter factor (HGF/SF) and epidermal growth factor (EGF) on cadherin-mediated adhesion of human carcinoma cells was studied. HGF/SF induced scattering ofExpand
Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor.
The role of phospholipase A2 (PLA2) in the cytotoxic action of tumor necrosis factor (TNF) was examined. Recently, we described the characterization of TNF-resistant sublines isolated fromExpand
Beta-catenin expression in human cancers.
Cell-cell adhesion in tissue is mainly regulated by homotypic interaction of cadherin molecules, which are anchored to the cytoskeleton via cytoplasmic proteins, including alpha- and beta-catenin.Expand
Aberrant expression and phosphorylation of beta-catenin in human colorectal cancer.
The cytoplasmic domain of cadherins is known to associate with the intracellular proteins, catenins, which link cadherins to the actin-based cytoskeleton. In this study, we immunohistochemicallyExpand
Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin
The hepatocyte growth factor/scatter factor (HGF/SF) receptor consists of an α‐ and a β‐subunit, which are derived from a single‐chain precursor by endoproteolytic processing. The precursor is notExpand
Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells.
The effect of hepatocyte growth factor/scatter factor (HGF/SF) and epidermal growth factor (EGF) on cadherin-mediated adhesion of human carcinoma cells was studied. HGF/SF induced scattering ofExpand
A Truncated β-Catenin Disrupts the Interaction between E-Cadherin and α-Catenin: A Cause of Loss of Intercellular Adhesiveness in Human Cancer Cell Lines
Cadherin cell adhesion molecules play an essential role in creating tight intercellular association and are considered to work as an invasion suppressor system of cancer cells. They form a molecularExpand
Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells*
The role of cytosolic phospholipase A2 (cPLA2) in the regulation of ceramide formation was examined in a cell line (L929) responsive to the cytotoxic action of tumor necrosis factor α (TNFα). In L929Expand
Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2.
Several lines of evidence have implicated lipid second messengers in the signaling pathways evoked by tumor necrosis factor (TNF). In a previous study, we characterized TNF-resistant sublines derivedExpand
Solubilization of human placental tumor necrosis factor receptors as a complex with a guanine nucleotide-binding protein.
Human placental membranes exhibited high-affinity receptors for tumor necrosis factor (TNF) (Kd = 5.6 x 10(-10) M) with a density of 1.2-1.7 x 10(10) sites/mg protein. The receptors were solubilizedExpand
...
1
2
3
4
5
...