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Synergism from combinations of cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models.
It is suggested that the addition of the phytochemical 2 h before platinum drug may sensitize cancer cells to platinum action, thus offering a means of overcoming drug resistance. Expand
Synergism from sequenced combinations of curcumin and epigallocatechin-3-gallate with cisplatin in the killing of human ovarian cancer cells.
The cellular accumulations of platinum and platinum-DNA binding resulting from the 0/4 h combinations were greater as compared to the values using Cis alone, thus providing an explanation for the synergistic action. Expand
Diarrheal illness in a cohort of children 0-2 years of age in rural Bangladesh: I. Incidence and risk factors.
- P. Pathela, K. Zahid Hasan, E. Roy, F. Huq, A. Kasem Siddique, R. Bradley Sack
- Acta paediatrica
- 1 April 2006
Most diarrheal episodes are of short duration, and should primarily be treated with oral rehydration therapy to prevent diarrhea-related mortality in young children in rural Bangladesh. Expand
Studies on the interaction between Cd(2+) ions and DNA.
The results suggest that Cd(2+) binds covalently with DNA (possibly at G, A and T centres) and can form intrastrand bifunctional AT adducts but not the GGAdducts. Expand
Studies on the interaction between Cd(2+) ions and nucleobases and nucleotides.
It is found that when Cd(2+) is allowed to interact with adenine and guanine, there is a marked change in the high performance liquid chromatography (HPLC) retention time forAdenine but not for Guanine. Expand
Synthesis, characterisation, activities, cell uptake and DNA binding of [[trans-PtCl(NH3)2] [mu-(H2N(CH2)6NH2)] [trans-PdCl(NH3)2](NO3)Cl.
- F. Huq, H. Daghriri, J. Yu, Hasan Tayyem, P. Beale, M. Zhang
- Chemistry, Medicine
- European journal of medicinal chemistry
- 1 November 2004
Increasing prevention of BamH1 digestion of form I and form II pBR322 plasmid DNA with the increase in concentration of DHD provides support to the idea that the interstrand binding of D HD with p BR322 plasid DNA brings about global changes in DNA conformation. Expand
Studies on the interaction between Ag(+) and DNA.
When pBR322 plasmid DNA was allowed to interact with silver(I) acetate, it was found to contain Form I and Form II bands whose intensity remained unchanged as the concentration of Ag(+) was increased, indicating the occurrence of increased covalent binding of the metal ion with DNA. Expand
Viral etiology of pneumonia in a cohort of newborns till 24 months of age in Rural Mirzapur, Bangladesh
- K. Hasan, P. Jolly, +5 authors R. Sack
- Scandinavian journal of infectious diseases
- 1 January 2006
Couning on avoiding crowding where a newborn is accommodated might reduce pneumonia incidence, and children living in a one-room house were 3 times more likely to develop viral pneumonia than childrenliving in a larger house. Expand
Synergism from combinations of tris(benzimidazole) monochloroplatinum(II) chloride with capsaicin, quercetin, curcumin and cisplatin in human ovarian cancer cell lines.
- Laila Arzuman, P. Beale, Charles Chan, J. Yu, F. Huq
- Chemistry, Medicine
- Anticancer research
- 1 October 2014
Greater activity of designed monofunctional platinum LH4 against resistant tumor models and synergism from combinations with phytochemicals indicate that the compound has the potential for development as a novel platinum-based anticancer drug. Expand
Synthesis of tris(quinoline)monochloroplatinum(II) Chloride and its Activity Alone and in Combination with Capsaicin and Curcumin in Human Ovarian Cancer Cell Lines.
Greater activity of LH5 compared to cisplatin, especially against the resistant cell lines, indicates that the compound may have the potential for development as a novel anticancer drug and that its combination with phytochemicals can serve to further enhance drug efficacy. Expand