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Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance
Mammalian cells repair DNA double-strand breaks (DSBs) via efficient pathways of direct, nonhomologous DNA end joining (NHEJ) and homologous recombination (HR). Prior work has identified a complex ofExpand
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Distinct Pathways of Nonhomologous End Joining That Are Differentially Regulated by DNA-dependent Protein Kinase-mediated Phosphorylation*
Nonhomologous end joining is the most common mechanism of DNA double-strand break repair in human cells. Here we show that nonhomologous end joining can occur by two biochemically distinct pathways.Expand
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Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility
BackgroundTransgelin is an actin-binding protein that promotes motility in normal cells. Although the role of transgelin in cancer is controversial, a number of studies have shown that elevatedExpand
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Nf1+/- monocytes/macrophages induce neointima formation via CCR2 activation.
Persons with neurofibromatosis type 1 (NF1) have a predisposition for premature and severe arterial stenosis. Mutations in the NF1 gene result in decreased expression of neurofibromin, a negativeExpand
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Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form.
The anticonvulsant phenytoin causes a decrease in plasma concentrations of folate in epileptic patients. The mechanism underlying this depletion is unknown. To study this mechanism, phenytoin wasExpand
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Increased Mutagenic Joining of Enzymatically-Induced DNA Double-Strand Breaks in High-Charge and Energy Particle Irradiated Human Cells
The carcinogenic risk of high-charge and energy (HZE) particle exposure arises from its ability to both induce complex DNA damage and from its ability to evoke deleterious, non-DNA targeted effects.Expand
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Rat liver subcellular folate distribution shows association of formyltetrahydropteroylpentaglutamates with mitochondria and methyltetrahydropteroylhexaglutamates with cytoplasm.
The ternary complex method for the determination of folylpolyglutamates was combined with procedures for interconverting folate derivatives to measure 28 different folate derivatives in theExpand
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Neurofibromin is a novel regulator of Ras-induced reactive oxygen species production in mice and humans.
Neurofibromatosis type 1 (NF1) predisposes individuals to early and debilitating cardiovascular disease. Loss of function mutations in the NF1 tumor suppressor gene, which encodes the proteinExpand
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Formyltetrahydrofolates associated with mitochondria have longer polyglutamate chains than the methyltetrahydrofolates associated with cytoplasm in rat brain.
The subcellular distribution of folate coenzymes in the brain is unknown. Brain folate concentrations are low and hence require a sensitive assay to determine the subcellular distribution. Rat brainExpand
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Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis
Neurofibromin, the protein product of the neurofibromatosis type 1 (NF1) tumor suppressor gene, is a negative regulator of Ras signaling. Patients with mutations in NF1 have a strong predispositionExpand
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