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Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance
Mammalian cells repair DNA double-strand breaks (DSBs) via efficient pathways of direct, nonhomologous DNA end joining (NHEJ) and homologous recombination (HR). Prior work has identified a complex of… Expand
Distinct Pathways of Nonhomologous End Joining That Are Differentially Regulated by DNA-dependent Protein Kinase-mediated Phosphorylation*
- D. Udayakumar, C. L. Bladen, F. Hudson, W. Dynan
- Biology, Medicine
- Journal of Biological Chemistry
- 24 October 2003
Nonhomologous end joining is the most common mechanism of DNA double-strand break repair in human cells. Here we show that nonhomologous end joining can occur by two biochemically distinct pathways.… Expand
Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility
BackgroundTransgelin is an actin-binding protein that promotes motility in normal cells. Although the role of transgelin in cancer is controversial, a number of studies have shown that elevated… Expand
Nf1+/- monocytes/macrophages induce neointima formation via CCR2 activation.
- W. Bessler, Grace Kim, +7 authors B. Stansfield
- Biology, Chemistry
- Human molecular genetics
- 15 March 2016
Persons with neurofibromatosis type 1 (NF1) have a predisposition for premature and severe arterial stenosis. Mutations in the NF1 gene result in decreased expression of neurofibromin, a negative… Expand
Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form.
The anticonvulsant phenytoin causes a decrease in plasma concentrations of folate in epileptic patients. The mechanism underlying this depletion is unknown. To study this mechanism, phenytoin was… Expand
Increased Mutagenic Joining of Enzymatically-Induced DNA Double-Strand Breaks in High-Charge and Energy Particle Irradiated Human Cells
The carcinogenic risk of high-charge and energy (HZE) particle exposure arises from its ability to both induce complex DNA damage and from its ability to evoke deleterious, non-DNA targeted effects.… Expand
Rat liver subcellular folate distribution shows association of formyltetrahydropteroylpentaglutamates with mitochondria and methyltetrahydropteroylhexaglutamates with cytoplasm.
The ternary complex method for the determination of folylpolyglutamates was combined with procedures for interconverting folate derivatives to measure 28 different folate derivatives in the… Expand
Neurofibromin is a novel regulator of Ras-induced reactive oxygen species production in mice and humans.
- W. Bessler, F. Hudson, +8 authors B. Stansfield
- Biology, Medicine
- Free radical biology & medicine
- 1 August 2016
Neurofibromatosis type 1 (NF1) predisposes individuals to early and debilitating cardiovascular disease. Loss of function mutations in the NF1 tumor suppressor gene, which encodes the protein… Expand
Formyltetrahydrofolates associated with mitochondria have longer polyglutamate chains than the methyltetrahydrofolates associated with cytoplasm in rat brain.
The subcellular distribution of folate coenzymes in the brain is unknown. Brain folate concentrations are low and hence require a sensitive assay to determine the subcellular distribution. Rat brain… Expand
Loss of GTPase activating protein neurofibromin stimulates paracrine cell communication via macropinocytosis
Neurofibromin, the protein product of the neurofibromatosis type 1 (NF1) tumor suppressor gene, is a negative regulator of Ras signaling. Patients with mutations in NF1 have a strong predisposition… Expand