• Publications
  • Influence
Inhibition by external Cd2+ of Na/Ca exchange and L-type Ca channel in rabbit ventricular myocytes.
We investigated the effect of external Cd2+ on the Na/Ca exchange and the L-type Ca channel current (ICa,L) in whole cell patch-clamped rabbit ventricular myocytes at 36 degrees C. After theExpand
  • 77
  • 6
Menthol Binding and Inhibition of α7-Nicotinic Acetylcholine Receptors
Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined. In this study we show an effect ofExpand
  • 42
  • 6
Menthol Inhibits 5-HT3 Receptor–Mediated Currents
The effects of alcohol monoterpene menthol, a major active ingredient of the peppermint plant, were tested on the function of human 5-hydroxytryptamine type 3 (5-HT3) receptors expressed in XenopusExpand
  • 31
  • 5
  • Open Access
Rate-dependent changes in cell shortening, intracellular Ca(2+) levels and membrane potential in single, isolated rainbow trout (Oncorhynchus mykiss) ventricular myocytes.
The effects of increasing stimulation frequency (from 0.2 to 1.4 Hz) on the contractility, intracellular Ca(2+) concentration ([Ca(2+)](i)) and membrane potential of single ventricular myocytesExpand
  • 42
  • 5
  • Open Access
Increased Oxidative Stress and Mitochondrial Dysfunction in Zucker Diabetic Rat Liver and Brain
Background/Aims: The Zucker diabetic fatty (ZDF, FA/FA) rat is a genetic model of type 2 diabetes, characterized by insulin resistance with progressive metabolic syndrome. We have previouslyExpand
  • 60
  • 3
Long‐term effects of streptozotocin‐induced diabetes on the electrocardiogram, physical activity and body temperature in rats
In vivo biotelemetry studies have demonstrated that short‐term streptozotocin (STZ)‐induced diabetes is associated with a reduction in heart rate (HR) and heart rate variability (HRV) andExpand
  • 75
  • 3
Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle
Abnormal QT prolongation with the associated arrhythmias is a significant predictor of mortality in diabetic patients. Gap junctional intercellular communication allows electrical coupling betweenExpand
  • 42
  • 3
Left ventricle structural remodelling in the prediabetic Goto–Kakizaki rat
This study tested the hypothesis that experimental prediabetes can elicit structural remodelling in the left ventricle (LV). Left ventricles isolated from 8‐week‐old male Goto–Kakizaki (GK) rats andExpand
  • 50
  • 3
Short‐term effects of streptozotocin‐induced diabetes on the electrocardiogram, physical activity and body temperature in rats
A variety of contractility defects have been reported in the streptozotocin (STZ)‐induced diabetic rat heart including alterations to the amplitude and time course of cardiac muscle contraction.Expand
  • 106
  • 2
Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart
It has been established that atherosclerotic coronary artery disease is more frequent and more severe in diabetic compared to non-diabetic subjects, but the reason for the excess risk of developingExpand
  • 61
  • 2