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Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
The inverse relationship of IFN-gamma and IL-4 gene expression during leishmaniasis may underlie the divergence of cellular and humoral immunity that occurs during chronic infection with Leishmania and possibly other intracellular parasites. Expand
Recombinant interleukin 12 cures mice infected with Leishmania major
It is concluded that rMuIL-12 prevents deleterious Th2 T cell responses and promotes curative Th1 responses in an IFN-gamma- dependent fashion during murine leishmaniasis. Expand
Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism
Data suggest a novel mechanism of cellular immunity established by interference with the development of Th2 cells during infection in BALB/c mice that was adoptively transferable and was dependent on both CD4+ and CD8+ cells. Expand
Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.
Data establish CD4+ cells as the primary source of IFN-gamma in healing mice and of IL-4 and IL-10 during progressive infection and confirm that the spectral extremes of this disease are characterized by the presence of CD4- cells expressing Th1 or Th2 phenotypes in vivo. Expand
Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon
A role for IL-12 as a proximal stimulator of IFN-gamma release during endotoxemia is supported, and T cells and B cells were magnetically purified from C57BL/6 mouse spleens 5 h following endotoxin injection. Expand
The role of IFN-gamma in the pathology of experimental endotoxemia.
  • F. Heinzel
  • Biology, Medicine
  • Journal of immunology
  • 1 November 1990
A significant role for IFN-gamma is demonstrated in the pathology of septic shock, both indirectly as an activator of monokines known to promote lethality and possibly by other, late-acting mechanisms. Expand
In vivo production and function of IL-12 p40 homodimers.
It is concluded that p40 homodimer is produced in vivo, functions as a cytokine antagonist in the context of the mouse model of acute endotoxemia, and may represent a novel form of self-regulating cytokine response. Expand
Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets.
The data are consistent with the expansion of type 1 helper cells during healing and type 2 helper cells (Th2) during progressive leishmania infection. Expand
Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection.
Mise en evidence du besoin en interferon gamma et en interleukine 4 lors de la presentation des antigenes parasitaires afin d'obtenir la maturation des sous populations cellulaires de cellules helperExpand
Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response.
It is demonstrated that Ag injected with IFA is as strongly immunogenic for T cells as it is with CFA, and that the presence of the mycobacteria determines not the priming of naive T cells through the second-signal link but the path of downstream differentiation toward CD4 memory cells that express either type-1 or type-2 cytokines. Expand