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A novel coronavirus outbreak of global health concern
The detection of infection in at least one household cluster— reported by Jasper Fuk-Woo Chan and colleagues in The Lancet—and the recently documented infections in health-care workers caring for patients with 2019-nCoV indicate human-to-human transmission and thus the risk of much wider spread of the disease. Expand
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care, and future trials in patients withsevere illness may help to confirm or exclude the possibility of a treatment benefit. Expand
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits, however, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies. Expand
Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)
The Surviving Sepsis Campaign CO VID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19, and will provide new recommendations in further releases of these guidelines. Expand
Kinetics of Influenza A Virus Infection in Humans
A series of mathematical models of increasing complexity, which incorporate target cell limitation and the innate interferon response, are utilized to examine influenza A virus kinetics in the upper respiratory tracts of experimentally infected adults to suggest that antiviral treatments have a large hurdle to overcome in moderating symptoms and limiting infectiousness. Expand
Avian influenza A (H5N1) infection in humans.
The writing committee consisted of the following: John H. Beigel, M.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.; Jeremy Farrar, D.Phil.,Expand
Seasonal influenza in adults and children--diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America.
These guidelines are intended for use by physicians in all medical specialties with direct patient care, because influenza virus infection is common in communities during influenza season and may be encountered by practitioners caring for a wide variety of patients. Expand
Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection.
Copyright © 2010 Massachusetts Medical Society. During the spring of 2009, a novel influenza A (H1N1) virus of swine origin caused human infection and acute respiratory illness in Mexico.1,2 AfterExpand
Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome
Corticosteroid therapy in patients with MERS was not associated with a difference in mortality after adjustment for time‐varying confounders but was associated with delayed MERS coronavirus RNA clearance. Expand
Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense.
It is found that IL-6 and IFN-alpha levels in nasal lavage fluids peaked early (day 2) and correlated directly with viral titers, temperature, mucus production, and symptom scores, which implicate IL- 6 and IFn-alpha as key factors both in symptom formation and host defense in influenza. Expand