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Toll-like receptors stimulate human neutrophil function.
TLDR
Using quantitative polymerase chain reaction (QPCR), a chemokine expression profile is demonstrated that suggests that TLR-stimulated neutrophils recruit innate, but not acquired, immune cells to sites of infection. Expand
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
TLDR
It is reported that mammalian TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and that activation of the receptor mobilizes the nuclear factor NF-κB and stimulates tumour necrosis factor-α production, and the data suggest thatTLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flageLLated bacterial pathogens. Expand
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility
TLDR
The exquisite ability of the innate immune system to precisely target a conserved site on flagellin that is essential for bacterial motility is demonstrated. Expand
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
TLDR
It is shown that DNA-containing immune complexes within lupus serum, but not protein-containing ICs from other autoimmune rheumatic diseases, stimulates plasmacytoid DCs to produce cytokines and chemokines via a cooperative interaction between Toll-like receptor 9 (TLR9) and FcgammaRIIa (CD32). Expand
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
TLDR
It is shown that for intact L. interrogans, it is LPS, not lipoprotein, that constitutes the predominant signaling component for macrophages through a TLR2 pathway, providing a basis for understanding the innate immune response caused by leptospirosis. Expand
The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells1
TLDR
It is demonstrated that flagellin can directly stimulate human but not murine DC maturation, providing an additional mechanism by which motile bacteria can initiate an acquired immune response. Expand
CCR4-dependent regulatory T cell function in inflammatory bowel disease
TLDR
It is demonstrated that CCR4 plays an important role in T Reg cell trafficking in LNs and that this is critical for T reg cell suppressive function in vivo. Expand
Serpin 2a Is Induced in Activated Macrophages and Conjugates to a Ubiquitin Homolog1
TLDR
It is demonstrated here that a ubiquitin homolog, IFN-stimulated gene of 15-kDa (ISG15), is strongly induced during in vitro and in vivo activation of macrophages and that it conjugates to spi2a in activated macrophades, the first ISG15-modified protein to be reported. Expand
Molecular Pathways of CTL‐mediated Cytotoxicity
TLDR
After the first description by Andre Govaerts of lymphocytes that could kill other cells, the lytic mechanism used in that process became one of the holy grailsof cellular immunology and led to renewed efforts to identify complement-like molecules associated with cell-mediated cytotoxicity (CMC) reactions in general. Expand
CCR 4-dependent regulatory T cell function in infl ammatory bowel disease
JEM © The Rockefeller University Press $15.00 Vol. 204, No. 6, June 11, 2007 1327–1334 www.jem.org/cgi/doi/10.1084/jem.20062076 1327 The pathogenesis of human infl ammatory bowel disease (IBD) isExpand
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