F. Hasler

Publications28
h-index17
Citations1,593
Highly Influential Citations102
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Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose–effect study
TLDR
PY affects core dimensions of altered states of consciousness and physiological parameters in a dose-dependent manner and provided no cause for concern that PY is hazardous with respect to somatic health.
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Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
TLDR
The results suggest that the administration of moderate doses of psilocybin to healthy, high-functioning and well-prepared subjects in the context of a carefully monitored research environment is associated with an acceptable level of risk.
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Determination of psilocin and 4-hydroxyindole-3-acetic acid in plasma by HPLC-ECD and pharmacokinetic profiles of oral and intravenous psilocybin in man.
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Effects of psilocybin on time perception and temporal control of behaviour in humans
TLDR
This study is the first to systematically assess the impact of psilocybin on timing performance on standardized measures of temporal processing, and indicates that the serotonin system is selectively involved in duration processing of intervals longer than 2 to 3 seconds and in the voluntary control of the speed of movement.
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Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans.
TLDR
Based on the single dose kinetics, the kinetic/dynamic analysis of the data revealed that after multiple doses of 1.
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Renal excretion profiles of psilocin following oral administration of psilocybin: a controlled study in man.
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Modulating the Rate and Rhythmicity of Perceptual Rivalry Alternations with the Mixed 5-HT2A and 5-HT1A Agonist Psilocybin
TLDR
The involvement of serotonergic pathways in binocular rivalry is suggested and supports the previously proposed role of a brainstem oscillator in perceptual rivalry alternations and symptoms of psychosis.
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Using Psilocybin to Investigate the Relationship between Attention, Working Memory, and the Serotonin 1A and 2A Receptors
TLDR
It is speculated that this impaired attentional performance may reflect a reduced ability to suppress or ignore distracting stimuli rather than reduced attentional capacity.
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Psilocybin links binocular rivalry switch rate to attention and subjective arousal levels in humans
TLDR
Together, these findings link changes in binocular rivalry switching rate to subjective levels of arousal and attention and suggest that psilocybin’s effect onbinocular rivalry is unlikely to be mediated by the 5-HT2A receptor.
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Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA
TLDR
The findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system.
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