• Publications
  • Influence
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique Fernando Pires Hartwig*, Neil Martin Davies, Gibran Hemani and GeorgeExpand
  • 150
  • 10
  • PDF
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
TLDR
A new method - the mode-based estimate (MBE) - is proposed to obtain a single causal effect estimate from multiple genetic instruments. Expand
  • 339
  • 9
  • PDF
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants fromExpand
  • 88
  • 7
  • PDF
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoralExpand
  • 82
  • 4
  • PDF
Inflammatory Biomarkers and Risk of Schizophrenia
Importance Positive associations between inflammatory biomarkers and risk of psychiatric disorders, including schizophrenia, have been reported in observational studies. However, conventionalExpand
  • 69
  • 4
Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption
TLDR
We propose a new method –the mode-based estimate (MBE) – is proposed to obtain a single causal effect estimate from multiple genetic instruments. Expand
  • 34
  • 4
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Summary Background Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heartExpand
  • 211
  • 3
  • PDF
Guidelines for performing Mendelian randomization investigations
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editorsExpand
  • 42
  • 3
Education and coronary heart disease: mendelian randomisation study
Objective To determine whether educational attainment is a causal risk factor in the development of coronary heart disease. Design Mendelian randomisation study, using genetic data as proxies forExpand
  • 103
  • 3
  • PDF
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behaviorExpand
  • 55
  • 2
  • PDF