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- Publications
- Influence
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
- F. Hartwig, N. Davies, G. Hemani, G. Davey Smith
- Biology, Medicine
- International journal of epidemiology
- 1 December 2016
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique Fernando Pires Hartwig*, Neil Martin Davies, Gibran Hemani and George… Expand
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
- F. Hartwig, G. Davey Smith, J. Bowden
- Computer Science, Medicine
- International journal of epidemiology
- 12 July 2017
TLDR
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
- Eleni Zengini, K. Hatzikotoulas, +20 authors E. Zeggini
- Biology, Medicine
- Nature Genetics
- 6 February 2018
Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from… Expand
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.
- C. Medina-Gomez, J. Kemp, +86 authors F. Rivadeneira
- Biology, Medicine
- American journal of human genetics
- 4 January 2018
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral… Expand
Inflammatory Biomarkers and Risk of Schizophrenia
- F. Hartwig, M. Borges, B. Horta, J. Bowden, G. Davey Smith
- Medicine
- JAMA psychiatry
- 1 November 2017
Importance Positive associations between inflammatory biomarkers and risk of psychiatric disorders, including schizophrenia, have been reported in observational studies. However, conventional… Expand
Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption
- F. Hartwig, G. Smith, Jack Bowden
- Computer Science, Mathematics
- 10 April 2017
TLDR
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
- A. F. Schmidt, D. Swerdlow, +130 authors N. Sattar
- Medicine
- The lancet. Diabetes & endocrinology
- 1 February 2017
Summary Background Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart… Expand
Guidelines for performing Mendelian randomization investigations
- S. Burgess, G. Davey Smith, +8 authors E. Theodoratou
- Computer Science, Medicine
- Wellcome open research
- 26 November 2019
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors… Expand
Education and coronary heart disease: mendelian randomisation study
- Taavi Tillmann, J. Vaucher, +14 authors M. Holmes
- Medicine
- British Medical Journal
- 30 August 2017
Objective To determine whether educational attainment is a causal risk factor in the development of coronary heart disease. Design Mendelian randomisation study, using genetic data as proxies for… Expand
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
- Y. J. Sung, T. Winkler, +294 authors D. Chasman
- Biology, Medicine
- American journal of human genetics
- 1 March 2018
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior… Expand