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Admissions to hospital caused by adverse drug reactions: cross sectional incidence study
The incidence of adverse reactions to drugs has been assessed with prospective epidemiological studies conducted within single units, departments, or hospitals.1–3 Because of the variability of theExpand
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Life-threatening adverse drug reactions at admission to medical intensive care: a prospective study in a teaching hospital
ObjectiveTo assess the characteristics of life-threatening adverse drug reactions in patients admitted to medical intensive care unit and to define those that could facilitate earlyExpand
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Bayesian pharmacovigilance signal detection methods revisited in a multiple comparison setting.
TLDR
We propose a new signal ranking procedure based on the posterior probability of null hypothesis of interest and make it possible to derive with a non-mixture modelling approach Bayesian estimators of the false discovery rate (FDR), false negative rate, sensitivity and specificity. Expand
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Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing
Objectives It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART. Methods This Europe-wide case–controlExpand
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Trends in Spontaneous Adverse Drug Reaction Reports to the French Pharmacovigilance System (1986—2001)
AbstractBackground: The French pharmacovigilance system is based on a network of 31 regional centres located in teaching hospitals and coordinated by the French Medicines Agency (‘Agence Francaise deExpand
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[The French system of evaluation of dependence: establishment in a legal system].
The French system of evaluation of dependence has been defined in the French Public Health Code by decree 99-249 of 31 March 1999. It was created by health authorities 10 years earlier and concernsExpand
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Agreement of expert judgment in causality assessment of adverse drug reactions
BackgroundGlobal introspection is, with operational algorithms and Bayes’ theorem, one of the three main approaches used to assess the causal relationship between a drug treatment and the occurrenceExpand
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Incidence of serious adverse drug reactions in general practice: A prospective study
Many studies have been conducted to estimate the incidence and economic impact of adverse drug reactions. Most of these studies used historical data or were based on single hospital units. Little isExpand
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[Validation of a measurement scale: example of a French Adverse Drug Reactions Preventability Scale].
Adverse drug reactions (ADRs) have been recognised as an important cause of hospital admission. Most of these drug-related admissions were expected ADRs and, thus, partly preventable. However, as farExpand
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