F. H. Wilson

Publications33
h-index20
Citations4,361
Highly Influential Citations317
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • R. Lifton
  • 448 Publications • 56,516 Citations
  • S. Hebert
  • 290 Publications • 24,968 Citations
  • J. Engelman
  • 352 Publications • 50,123 Citations
  • K. Kahle
  • 206 Publications • 9,447 Citations
  • Publications
  • Influence
Human Hypertension Caused by Mutations in WNK Kinases
Hypertension is a major public health problem of largely unknown cause. Here, we identify two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring hypertension, increased renal… Expand
  • 1,264
  • 114
  • PDF
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion
A key question in systems biology is how diverse physiologic processes are integrated to produce global homeostasis. Genetic analysis can contribute by identifying genes that perturb this… Expand
  • 361
  • 36
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na–Cl cotransporter is inhibited by wild-type but not mutant WNK4
Mutations in the serine-threonine kinases WNK1 and WNK4 [with no lysine (K) at a key catalytic residue] cause pseudohypoaldosteronism type II (PHAII), a Mendelian disease featuring hypertension,… Expand
  • 387
  • 22
  • PDF
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis
The steroid hormone aldosterone is secreted both in the setting of intravascular volume depletion and hyperkalemia, raising the question of how the kidney maximizes NaCl reabsorption in the former… Expand
  • 140
  • 21
  • PDF
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo
Homeostasis of intravascular volume, Na+, Cl−, and K+ is interdependent and determined by the coordinated activities of structurally diverse mediators in the distal nephron and the distal colon. The… Expand
  • 112
  • 21
  • PDF
Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.
Haploinsufficiency for ribosomal protein genes has been implicated in the pathophysiology of Diamond-Blackfan anemia (DBA) and the 5q-syndrome, a subtype of myelodysplastic syndrome. The p53 pathway… Expand
  • 300
  • 16
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.
WNK1 and WNK4 [WNK, with no lysine (K)] are serine-threonine kinases that function as molecular switches, eliciting coordinated effects on diverse ion transport pathways to maintain homeostasis… Expand
  • 180
  • 15
  • PDF
WNK4 regulates apical and basolateral Cl– flux in extrarenal epithelia
Mutations in the serine-threonine kinase WNK4 [with no lysine (K) 4] cause pseudohypoaldosteronism type II, a Mendelian disease featuring hypertension with hyperkalemia. In the kidney, WNK4 regulates… Expand
  • 172
  • 13
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
Tumors put in a vulnerable position Cancer cells often display alterations in metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by… Expand
  • 192
  • 12
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
Paracellular ion flux across epithelia occurs through selective and regulated pores in tight junctions; this process is poorly understood. Mutations in the kinase WNK4 cause pseudohypoaldosteronism… Expand
  • 164
  • 10
  • PDF
...
1
2
3
4
...