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Acquired tumor cell radiation resistance at the treatment site is mediated through radiation-orchestrated intercellular communication.
PURPOSE Radiation resistance induced in cancer cells that survive after radiation therapy (RT) could be associated with increased radiation protection, limiting the therapeutic benefit of radiation.Expand
Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes
BackgroundDetermining the driving factors and molecular flow-through that define the switch from favorable to aggressive high-risk disease is critical to the betterment of neuroblastomaExpand
Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling
IntroductionHigh-risk neuroblastoma (HR-NB) presenting with hematogenous metastasis is one of the most difficult cancers to cure. Patient survival is poor. Aggressive tumors contain populations ofExpand
Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells
BackgroundMetastamiRs have momentous clinical relevance and have been correlated with disease progression in many tumors. In this study, we identified neuroblastoma metastamiRs exploiting uniqueExpand
Erratum to: Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling
High-risk neuroblastoma (HR-NB) presenting with hematogenous metastasis is one of the most difficult cancers to cure. Patient survival is poor. Aggressive tumors contain populations of rapidlyExpand
Abscopal effect of low-LET γ-radiation mediated through Rel protein signal transduction in a mouse model of nontargeted radiation response
Ascertaining the ionizing radiation (IR)-induced bystander response and its preceding molecular regulation would increase our understanding of the mechanism of acute and delayed radiobiologicalExpand
RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes
Clinical outcomes for high-risk neuroblastoma patients remains poor, with only 40–50% 5-Year overall survival (OS) and <10% long-term survival. The ongoing acquisition of genetic/molecularExpand
Abstract 5229: Profiling of circulating miRNAs is a critical prognostic biomarker tool for high-risk neuroblastoma
Circulating miRNAs has momentous clinical relevance and has been correlated with disease progression in many solid tumors. In this study, we investigated the circulating miRNAs9 variations exploitingExpand
The Role of Nitric Oxide in Cancer: Master Regulator or NOt?
Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis depending on the source and concentration of NO. In this review, we discuss the mechanisms by which NOExpand
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