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Role of 5-HT in stress, anxiety, and depression
TLDR
It is found that 24 h after electrolytic lesion of the rat MRN glandular gastric ulcers occurred, and the immune response to the mitogen concanavalin A was depressed, these results are compatible with the hypothesis that the MRN-dorsal hippocampus 5-HT system attenuates stress by facilitation of hippocampal 5- HT1A-mediated neurotransmission. Expand
Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
TLDR
Results suggest the CBD interacts with 5HT1A receptors to produce anxiolytic effects in the dlPAG, which is a midbrain structure related to anxiety that contains receptors proposed to interact with CBD such as 5 HT1A. Expand
Antianxiety effect of cannabidiol in the elevated plus-maze
TLDR
It is indicated that CBD causes a selective anxiolytic effect in the elevated plus-maze model of anxiety, within a limited range of doses. Expand
5‐HT1A receptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
TLDR
The hypothesis that CBD would attenuate the autonomic and behavioural consequences of restraint stress (RS) was tested and it was investigated if the responses to CBD depended on activation of 5‐HT1A receptors. Expand
The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.
TLDR
Findings support that the anxiolytic effect of chronic CBD administration in stressed mice depends on its proneurogenic action in the adult hippocampus by facilitating endocannabinoid-mediated signalling. Expand
Antidepressant‐like effects of cannabidiol in mice: possible involvement of 5‐HT1A receptors
TLDR
The hypothesis that CBD would have antidepressant‐like activity in mice as assessed by the forced swimming test was tested and it was investigated if these responses depended on the activation of 5‐HT1A receptors and on hippocampal expression of brain‐derived neurotrophic factor (BDNF). Expand
Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.
TLDR
The results of two studies on healthy volunteers using perception of binocular depth inversion and ketamine-induced psychotic symptoms supported the proposal of the antipsychotic-like properties of CBD and confirmed that this cannabinoid can be a safe and well-tolerated alternative treatment for schizophrenia. Expand
Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
TLDR
Recent in vivo studies indicating that the mechanisms responsible for CBD therapeutic potential are not unitary but rather depend on the behavioural response being measured suggest activation of TRPV1 channels may help to explain the antipsychotic effect and the bell-shaped dose-response curves commonly observed with CBD. Expand
Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice.
TLDR
Test the hypothesis that cannabidiol would inhibit the hyperlocomotion induced by two psychotomimetic drugs, D-amphetamine or ketamine and found that it exhibits an antipsychotic-like profile without inducing extrapyramidal-like effects. Expand
Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice
TLDR
The results give further support to the hypothesis that NO plays a role in motor behavior control and suggest that it may take part in the synaptic changes produced by antipsychotic treatment. Expand
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