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Proneural genes and the specification of neural cell types
TLDR
Parallel studies in Drosophila and vertebrates have revealed that proneural genes are key regulators of neurogenesis, coordinating the acquisition of a generic neuronal fate and of specific subtype identities that are appropriate for the location and time of neuronal generation.
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Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells
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neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.
TLDR
Ngn3 is required for the specification of a common precursor for the four pancreatic endocrine cell types, and it is shown that ngn3-positive cells coexpress neither insulin nor glucagon, suggesting thatngn3 marks early precursors of pancreaticendocrine cells.
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Control of endodermal endocrine development by Hes-1
TLDR
It is shown that mice deficient in Hes1 (encoding Hes-1) display severe pancreatic hypoplasia caused by depletion of pancreatic epithelial precursors due to accelerated differentiation of post-mitotic endocrine cells expressing glucagon, and upregulation of several bHLH components is associated with precocious and excessive differentiation of multiple endocrine cell types in the developing stomach and gut, showing that Hes- 1 operates as a general negative regulator of endodermal endocrine differentiation.
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A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons.
TLDR
The results indicate that in addition to acting as neuronal determinants, Mash1 and Ngns play a role in the specification of dorsal-ventral neuronal identity, directly linking pathways of neurogenesis and regional patterning in the forebrain.
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Essential role of Mash-2 in extraembryonic development
TLDR
Mash-2 is the first transcription factor shown to play a critical part in the development of the mammalian trophoblast lineage and rescued this placental mutant phenotype by constructing chimaeras with tetraploid wild-type embryos which contribute almost exclusively to extraembryonic tissues.
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Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
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Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
TLDR
It is demonstrated that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation in neural precursor cells prepared from wild‐type, Hes1‐null, Hes5‐null and Hes1-Hes5 double‐null mouse embryos.
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Mash1 regulates neurogenesis in the ventral telencephalon.
TLDR
Mash1 is an important regulator of neurogenesis in the ventral telencephalon, where it is required both to specify neuronal precursors and to control the timing of their production.
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Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia.
TLDR
Data reveal remarkable parallels in the roles of bHLH factors during neurogenesis in the DRG, and myogenesis in the neighboring myotome, suggesting that feedback or competitive interactions between these precursors may control the proportion of different neuronal subtypes they normally produce.
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