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Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship.
- T. Cresteil, B. Monsarrat, J. Dubois, M. Sonnier, P. Alvinerie, F. Guéritte
- Chemistry, BiologyDrug metabolism and disposition: the biological…
- 1 April 2002
Data strongly suggested that the structure of the lateral chain and the nature of substituent in position 10 play an important role in determining the regioselective oxidation by P450 proteins and modulate the reaction rate by human liver microsomes.
Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri.
Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi.
Even though several extracts and fractions showed significant selective antiviral activity in the CHIKV virus-cell-based assay, none of the purified compounds did, and significant inhibition was observed with betulinic acid 3β-caffeate in the DENV RNA polymerase assay.
Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.
In an effort to discover potent inhibitors of the antiapoptotic protein Bcl-xL, a systematic in vitro evaluation was undertaken on extracts prepared from various parts of Vietnamese plants, leading to the isolation of 15 pentacyclic triterpenoids.
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication.
A chemical study of the Vietnamese plant species Trigonostemon howii led to the isolation of a new tigliane-type diterpenoid, trigowiin A (1), which exhibited moderate antiviral activity in a virus-cell-based assay for Chikungunya virus (CHIKV).
Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis
One new drimane-type sesquiterpenoid was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimanes- type sesQUiterpenoids, establishing their structures by detailed spectroscopic analysis.
Chemical constituents of Anacolosa pervilleana and their antiviral activities.
Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora.
One new norlignan and five new lignans were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification, and most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 cancer cell lines.
New Synthesis of Benzo-δ-carbolines, Cryptolepines, and Their Salts: In Vitro Cytotoxic, Antiplasmodial, and Antitrypanosomal Activities of δ-Carbolines, Benzo-δ-carbolines, and Cryptolepines
A new synthesis of benzo-δ-carbolines, cryptolepines, and their salts is described, based on the association between halogen-dance and hetero-ring cross-coupling, with interesting overall yields from 27% to 70%.
Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors.
Chartaceones represent a new class of non-nucleosidic inhibitors of the DENV NS5 RdRp, and are distinguished using extensive one- and two-dimensional NMR spectroscopy.