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Cholinergic nicotinic receptors: Competitive ligands, allosteric modulators, and their potential applications
Discovery of the important role played by nicotinic acetylcholine receptors (nAChRs) in several CNS disorders has called attention to these membrane proteins and to ligands able to modulate theirExpand
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The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR).
Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer cells to chemotherapic drugs that are characterized by different chemical structure and different mechanism ofExpand
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Central Nicotinic Receptors: Structure, Function, Ligands, and Therapeutic Potential
The growing interest in nicotinic receptors, because of their wide expression in neuronal and non‐neuronal tissues and their involvement in several important CNS pathologies, has stimulated theExpand
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Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8.
The antinociceptive effect of two 5-HT4 agonists, BIMU 1 and BIMU 8, were examined in mice and rats by using the hot-plate, abdominal constriction and paw-pressure tests. In both species, BIMU 1Expand
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Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain.
Several compounds with a 4-aminopiperidine scaffold decorated on both nitrogen atoms by alkyl or acyl moieties containing the structural motifs of verapamil and of flunarizine, as well as those thatExpand
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DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer
Abstract. DM235 (sunifiram), a new compound structurally related to piracetam, prevented the amnesia induced by scopolamine (1.5 mg kg–1 i.p.), after intraperitoneal (0.001–0.1 mg kg–1) or oralExpand
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The medicinal chemistry of multidrug resistance (MDR) reversing drugs.
Multidrug resistance (MDR) is a kind of resistance of cancer cells to multiple classes of chemotherapic drugs that can be structurally and mechanistically unrelated. Classical MDR regards alteredExpand
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Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs.
Cognition enhancers are drugs able to facilitate attentional abilities and acquisition, storage and retrieval of information, and to attenuate the impairment of cognitive functions associated withExpand
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Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP).
DMPP is a well-known nicotinic agonist that does not fit any proposed pharmacophore for nicotinic binding and represents a unique ligand among the hundreds of nicotinic agonists studied in the pastExpand
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Design, synthesis, and in vitro activity of catamphiphilic reverters of multidrug resistance: discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range.
On the basis of the results obtained in previous research, three series of compounds (A-C), derived from verapamil, were designed and synthesized to obtain drugs able to revert multidrug resistanceExpand
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