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Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer.
- P. Salama, M. Phillips, +5 authors B. Iacopetta
- Journal of clinical oncology : official journal…
- 10 January 2009
PURPOSE To determine the prognostic significance of FOXP3(+) lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8(+) and CD45RO(+)… Expand
Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer
BACKGROUND Adjuvant chemotherapy can improve 5-year survival in Dukes' C colorectal carcinoma. Improved selection of patients who will respond to adjuvant treatments is required. We investigated… Expand
P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma.
- H. Elsaleh, B. Powell, +4 authors B. Iacopetta
- Medicine, Biology
- Clinical cancer research : an official journal of…
- 1 May 2001
PURPOSE We recently presented evidence for tumor site and gender-specificity in the survival benefit from adjuvant chemotherapy in Stage III colorectal cancer (CRC). In the current study, we examined… Expand
Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands
Background and aims: A subgroup of colorectal cancers (CRC) referred to as the CpG island methylator phenotype (CIMP+) shows simultaneous methylation of multiple CpG islands. The clinicopathological… Expand
PIK3CA mutations in breast cancer are associated with poor outcome
SummaryThe phosphatidylinositol-3-kinase (PI3K)–AKT signaling pathway is considered to play an important role in tumorigenesis. Frequent somatic mutations in the PI3K subunit p110α (PIK3CA) occur in… Expand
DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer
- K. Kawakami, A. Ruszkiewicz, +4 authors B. Iacopetta
- Biology, Medicine
- British Journal of Cancer
- 17 January 2006
The CpG-island methylator phenotype (CIMP+) in colorectal cancer (CRC) is characterised by frequent hypermethylation of promoter regions in tumour suppressor genes. Low level methylation of some CpG… Expand
Methylation levels of LINE‐1 repeats and CpG island loci are inversely related in normal colonic mucosa
Hypermethylation of CpG island loci within gene promoter regions is a frequent event in colorectal cancer that is often associated with transcriptional silencing and has been referred to as CIMP+.… Expand
Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features
BackgroundMost previous studies of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been conducted on a relatively small numbers of CpG sites. In the present study we… Expand
Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers.
BACKGROUND The aim of this case-control study was to investigate whether the common G870A polymorphism in the Cyclin D1 gene (CCND1) is a risk factor for breast and colorectal cancers in an… Expand
Population‐based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test
Approximately 1–2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and… Expand