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CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
The transport of Toll-like Receptors (TLRs) to various organelles has emerged as an essential means by which innate immunity is regulated. While most of our knowledge is restricted to regulators thatExpand
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Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Penetration of the gut mucosa by pathogens expressing invasion genes is believed to occur mainly through specialized epithelial cells, called M cells, that are located in Peyer's patches. However,Expand
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Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures
The signals controlling the checkpoints of dendritic cells (DC) maturation and the correlation between phenotypical and functional maturational stages were investigated in a defined model system ofExpand
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Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
Dendritic cells (DCs) are strong activators of primary T cell responses. Their priming ability is acquired upon encounter with maturation stimuli. To identify the genes that are differentiallyExpand
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CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
Toll-like receptors (TLRs) are the best characterized pattern recognition receptors. Individual TLRs recruit diverse combinations of adaptor proteins, triggering signal transduction pathways andExpand
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IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function
Interferon-λ (IFN-λ) is a central regulator of mucosal immunity; however, its signaling specificity relative to that of type I interferons is poorly defined. IFN-λ can induce antiviralExpand
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Coordinated events during bacteria-induced DC maturation.
Abstract The dendritic cell (DC) system represents a class of professional antigen-presenting cells whose primary function is to regulate the initiation of immune responses. Here, Maria Rescigno andExpand
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A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model toExpand
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Transcriptional reprogramming of dendritic cells by differentiation stimuli
Immature and mature dendritic cells (DC) have been well characterized functionally and phenotypically. Microorganisms or bacterial products such as lipopolysaccharide (LPS) and inflammatoryExpand
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Role of CD14 in host protection against infections and in metabolism regulation
CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment. CD14Expand
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