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- Publications
- Influence
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
- I. Zanoni, Renato Ostuni, +5 authors J. Kagan
- Biology, Medicine
- Cell
- 11 November 2011
The transport of Toll-like Receptors (TLRs) to various organelles has emerged as an essential means by which innate immunity is regulated. While most of our knowledge is restricted to regulators that… Expand
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
- M. Rescigno, M. Urbano, +6 authors P. Ricciardi-Castagnoli
- Biology, Medicine
- Nature Immunology
- 1 April 2001
Penetration of the gut mucosa by pathogens expressing invasion genes is believed to occur mainly through specialized epithelial cells, called M cells, that are located in Peyer's patches. However,… Expand
Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures
- C. Winzler, P. Rovere, +6 authors P. Ricciardi-Castagnoli
- Biology, Medicine
- The Journal of experimental medicine
- 20 January 1997
The signals controlling the checkpoints of dendritic cells (DC) maturation and the correlation between phenotypical and functional maturational stages were investigated in a defined model system of… Expand
Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
- F. Granucci, C. Vizzardelli, +6 authors P. Ricciardi-Castagnoli
- Biology, Medicine
- Nature Immunology
- 1 September 2001
Dendritic cells (DCs) are strong activators of primary T cell responses. Their priming ability is acquired upon encounter with maturation stimuli. To identify the genes that are differentially… Expand
CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
- I. Zanoni, Renato Ostuni, +11 authors F. Granucci
- Biology, Medicine
- Nature
- 9 July 2009
Toll-like receptors (TLRs) are the best characterized pattern recognition receptors. Individual TLRs recruit diverse combinations of adaptor proteins, triggering signal transduction pathways and… Expand
IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function
- A. Broggi, Y. Tan, F. Granucci, I. Zanoni
- Chemistry, Medicine
- Nature Immunology
- 28 August 2017
Interferon-λ (IFN-λ) is a central regulator of mucosal immunity; however, its signaling specificity relative to that of type I interferons is poorly defined. IFN-λ can induce antiviral… Expand
Coordinated events during bacteria-induced DC maturation.
- M. Rescigno, F. Granucci, S. Citterio, M. Foti, P. Ricciardi-Castagnoli
- Biology, Medicine
- Immunology today
- 1 May 1999
Abstract The dendritic cell (DC) system represents a class of professional antigen-presenting cells whose primary function is to regulate the initiation of immune responses. Here, Maria Rescigno and… Expand
A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
- F. Granucci, I. Zanoni, +5 authors P. Ricciardi-Castagnoli
- Biology, Medicine
- The Journal of experimental medicine
- 2 August 2004
Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to… Expand
Transcriptional reprogramming of dendritic cells by differentiation stimuli
- F. Granucci, C. Vizzardelli, E. Virzi, M. Rescigno, P. Ricciardi-Castagnoli
- Biology, Medicine
- European journal of immunology
- 1 September 2001
Immature and mature dendritic cells (DC) have been well characterized functionally and phenotypically. Microorganisms or bacterial products such as lipopolysaccharide (LPS) and inflammatory… Expand
Role of CD14 in host protection against infections and in metabolism regulation
- I. Zanoni, F. Granucci
- Biology, Medicine
- Front. Cell. Infect. Microbiol.
- 24 July 2013
CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment. CD14… Expand
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